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| 载脂蛋白E基因多态性与疾病的相关性研究 | |
| 引用本文： | 付盼,王传清,何磊燕. 载脂蛋白E基因多态性与疾病的相关性研究[J]. 国际免疫学杂志, 2011, 34(1): 61-64. DOI: 10.3760/cma.j.issn.1673-4394.2011.01.016 |
| 作者姓名： | 付盼 王传清 何磊燕 |
| 作者单位： | 复旦大学附属儿科医院,上海,201102 |
| 摘 要： | 载脂蛋白E（ApoE）是一种重要的血浆脂蛋白，由3种等位基因构成：E2、E3和E4。ApoE作为一种载脂蛋白，在脂质运输和代谢过程中发挥重要作用，而目前越来越多的研究表明：ApoE在免疫调节方面发挥重要作用，从而参与到多种疾病的发生发展中。近年来发现，ApoE及其基因多态性与高脂血症、动脉粥样硬化、Alzheimer病、神经系统病变及脓毒血症等人类疾患的发生发展有着密切关系。 |
| 关 键 词： | 载脂蛋白E 基因多态性 疾病 |
Relationship between apolipoprotein E gene polymorphism and disease |
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| FU Pan,WANG Chuan-qing,HE Lei-yan. Relationship between apolipoprotein E gene polymorphism and disease[J]. International Journal of Immunology, 2011, 34(1): 61-64. DOI: 10.3760/cma.j.issn.1673-4394.2011.01.016 | |
| Authors: | FU Pan WANG Chuan-qing HE Lei-yan |
| Affiliation: | . (Children＇ s Hospital of Fudan University, Shanghai 201102, China) |
| Abstract: | Apolipoprotein E (ApoE), an important plasma lipoprotein, which has three isforms, E2,E3 and E4,plays an critical role in lipid transport and metabolism. Many studies showed ApoE also had immunoregulaory effect. It is suggested that ApoE may involved in the development of many diseases. ApoE and its gene polymorphism had a strong relationship with a variety diseases, such as hyperlipidemia, atherosclerosis,Alzheimer's diseases, diseaseses of Nervous system diseases and sepsis. |
| Keywords: | Apolipoprotein E Gene polymorphism Disease |
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