无肝素抗凝连续性血液净化治疗对脓毒症患者凝血功能的影响

目的 观察无肝素抗凝连续性血液净化治疗对脓毒症患者凝血功能的影响.方法 对27例脓毒症患者行49例次无肝素抗凝连续性血液净化治疗,在治疗前、治疗后及治疗后第3天观察患者急性生理学与慢性健康状况评分Ⅱ(APACHEⅡ评分)及凝血功能相关参数的变化.结果 治疗后凝血酶原时间、活化部分凝血活酶时间均较治疗前延长(P＜0.05),纤维蛋白原下降;连续性血液净化治疗后第3天,APACHEⅡ评分下降,凝血酶原时间、活化部分凝血活酶时间仍延长,与常规治疗组比较差异有统计学意义(P＜0.05).结论 连续性血液净化是治疗严重脓毒症的有效措施之一,能改善患者凝血紊乱状态,其机制可能与多种因素有关.

Abstract：

Objective To evaluate the effect of continuous blood purification(CBP) without anticoagulation on the function of coagulation in the patients with severe sepsis. Methods 49 times CBP without anticoagulation were used in 27 patients with severe sepsis. APACHE Ⅱ score and some parameters of coagulation function in pre-CBP,post-CBP and the 3rd day after CBP were studied and compared. Results TT,APTT were longer in post-CBP and on the 3rd day after CBP than in pre-CBP ( P ＜ 0.05), Fg decreased significantly compared with control group. APACHE Ⅱ after CBP lowered obviously compared with pre-CBP (P＜0.01).Conclusion CBP is one of effective methods for the patients with severe sepsis, and can improve the coagulation function of these patients.

Effect of continuous blood purification without anticoagulation on the function of coagulation in the patients with severe sepsis

Objective To evaluate the effect of continuous blood purification(CBP) without anticoagulation on the function of coagulation in the patients with severe sepsis. Methods 49 times CBP without anticoagulation were used in 27 patients with severe sepsis. APACHE Ⅱ score and some parameters of coagulation function in pre-CBP,post-CBP and the 3rd day after CBP were studied and compared. Results TT,APTT were longer in post-CBP and on the 3rd day after CBP than in pre-CBP ( P ＜ 0.05), Fg decreased significantly compared with control group. APACHE Ⅱ after CBP lowered obviously compared with pre-CBP (P＜0.01).Conclusion CBP is one of effective methods for the patients with severe sepsis, and can improve the coagulation function of these patients.