| 小儿支气管哮喘免疫功能研究 |
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| 引用本文： | 蔡幸生,余华斐,林丽爱,朱勇斌,张淳,陈尤佳. 小儿支气管哮喘免疫功能研究[J]. 国际医药卫生导报, 2011, 17(4): 390-393. DOI: 10.3760/cma.j.issn.1007-1245.2011.04.003 |
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| 作者姓名： | 蔡幸生 余华斐 林丽爱 朱勇斌 张淳 陈尤佳 |
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| 作者单位： | 蔡幸生 (揭阳市人民医院,522000) ； 余华斐 (揭阳市人民医院,522000) ； 林丽爱 (揭阳市榕城区妇幼保健院,522000) ； 朱勇斌 (揭阳市人民医院,522000) ； 张淳 (揭阳市人民医院,522000) ； 陈尤佳 (揭阳市人民医院,522000) ； |
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| 基金项目： | 揭阳市卫生局医学科研项目 |
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| 摘 要： | 目的 探讨小儿哮喘的免疫功能状态,为该病免疫调节治疗提供科学依据.方法 对10年来我院收治的77例支气管哮喘患儿进行总Ig、IgG、IgA、IgM、IgE及T淋巴细胞亚群检测,并与我院同龄儿正常值进行比较.并对CD3、CD4、CD8、CD4/CD8与总Ig、IgG、IgA、IgE进行相关性分析.结果 患儿总Ig、IgG...
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| 关 键 词： | 哮喘 儿童 T淋巴细胞亚群 免疫球蛋白 |
A study on immunologic function in children with bronchial asthma |
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| CAI Xing-sheng,YU Hua-fei,LIN Li-ai,ZHU Yong-hin,HANG Chun,CHEN You-jia. A study on immunologic function in children with bronchial asthma[J]. International Medicine & Health Guidance News, 2011, 17(4): 390-393. DOI: 10.3760/cma.j.issn.1007-1245.2011.04.003 |
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| Authors: | CAI Xing-sheng YU Hua-fei LIN Li-ai ZHU Yong-hin HANG Chun CHEN You-jia |
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| Affiliation: | CAI Xing-sheng(Jieyang People＇s Hospital, Jieyang 522000, China) YU Hua-fei(Jieyang People＇s Hospital, Jieyang 522000, China) LIN Li-ai ZHU Yong-hin(Jieyang People＇s Hospital, Jieyang 522000, China) HANG Chun(Jieyang People＇s Hospital, Jieyang 522000, China) CHEN You-jia(Jieyang People＇s Hospital, Jieyang 522000, China) |
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| Abstract: | Objective To investigate the immune function of children with asthma for offering scientific evidence of immunological regulation in treatment children with asthma,. Methods Total-Ig, IgG,IgA, IgM, IgE, CD3, CD4, CD8, CD4/CD8 were detected in 77 cases with asthma. The results were compared with normal value of children of the same age in our hospital. The correlations were analyzed between CD3,CD4, CD8, CD4/CD8 with IgG, IgA, IgE. Results Total-Ig, IgC, IgA, CD4, CD4/CD8 were significantly lower in children with asthma than that of normal value(P＜0.01, respectively), CD3, CD8 were lower in children with asthma than normal value(P＜0.05, respectively), IgE was significantly higher in children with asthma than normal value(P＜0.01), IgM had no significant difference ( P＞0.05). There were positive correlation between CD3 with Total-Ig, IgG, IgA(P＜0.05). There were significant positive correlation between CD4, CD4/CD8 with Total - Ig, IgG, IgA(P＜0.01). There were significant negative correlation between CD8, CD4/CD8 with IgE (P＜ 0.01). Conclusion There were cellular immune functional defect and humoral immune functional disorder in children with asthma. Adjusting the immune function should be emphasized in treatment to children with asthma. |
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| Keywords: | Asthma Children T lymphocyte subsets Immunoglobulin |
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