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Swimming capacity of mice after prolonged treatment with psychostimulants
Authors:C. -J. Estler  M. K. Gabrys
Affiliation:(1) Institute of Pharmacology and Toxicology, University of Erlangen-Nürnberg, Universitätsstr. 22, D-8520 Erlangen, Germany
Abstract:The effect of long-term treatment with fencamfamine on swimming endurance and availability of metabolic substrates was investigated in mice. Fencamfamine (14 mgrg/g per day orally for 6 weeks) reduced maximum swimming capacity by more than 40%. This effect could not be attributed to motor incoordination or a diminution of pre-swimming levels of metabolic substrates such as liver and muscle glycogen or blood glucose and non-esterified fatty acids. However, during swimming the hepatic and muscular glycogen stores were depleted more rapidly in the fencamfamine-treated animals. Thus it appears that fencamfamine leads more rapidly to a shortage of combustible substrates in the swimming animals.
Keywords:Fencamfamine  Swimming capacity  Motor behaviour  Carbohydrate metabolism  Lipid metabolism
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