| 支气管哮喘患儿外周血淋巴细胞CD19~+CD23~+和CD4~+CD25~+的表达及意义 |
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| 引用本文： | 严波.支气管哮喘患儿外周血淋巴细胞CD19~+CD23~+和CD4~+CD25~+的表达及意义[J].全科医学临床与教育,2010,8(2):148-150. |
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| 作者姓名： | 严波 |
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| 作者单位： | 临安市人民医院儿科,浙江临安,311300 |
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| 摘 要： | 目的探讨支气管哮喘患儿外周血淋巴细胞CD19＋CD23＋和CD4＋CD25＋的表达及意义。方法采用流式细胞分析技术及免疫化学发光法分别检测34例哮喘发作期（哮喘发作组）和32例哮喘缓解期（哮喘缓解组）外周血CD19＋CD23＋表达率、CD4＋CD25＋表达率和血清总IgE水平，并与25例体检儿童（对照组）进行比较。结果哮喘发作组外周血CD19＋CD23＋表达率为（19.31±9．08）％分别高于哮喘缓解组（8．63±3．54）％和对照组；哮喘发作组CD4＋CD25＋表达率为（2．79±1．69）％和哮喘缓解组为（3.36±1．17）％均低于对照组；哮喘发作组IgE水平为（177．01±90．38）IU/ml和哮喘缓解组为（160．76±77．54）IU／ml均高于对照组．三组的差异均有统计学意义（F分别=36．62、24．67、24．35，P均〈0．05）。CD19＋CD23＋表达率与IgE呈正相关，CD4＋CD25＋表达率和IgE呈明显负相关，CD19＋CD23＋表达率和CD4＋CD25＋表达率亦呈明显负相关，差异均有统计学意义（r分别：0．22、-0．41、-0．34，P均〈0．05）。结论哮喘急性发作时外周血CD19＋CD23＋和CD4＋CD25＋改变明显。
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| 关 键 词： | 支气管哮喘 淋巴细胞 CD19＋CD23＋ CD4＋CD25＋ |
Expression and significance of CD19~+CD23~+ and CD4~+CD25~+ in peripheral blood lymphocytes in children with bronchial asthma |
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| YANBo.Pediatric.Expression and significance of CD19~+CD23~+ and CD4~+CD25~+ in peripheral blood lymphocytes in children with bronchial asthma[J].clinical education of general practice,2010,8(2):148-150. |
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| Authors: | YANBoPediatric |
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| Institution: | YAN+Bo.+Pediatric+Department,The+People%5c's+Hospital+of+Linan,Linan+311300,China |
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| Abstract: | Objective To investigate the expression and significance of CD19+CD23+ and CD4+CD25+ in peripheral blood lymphocytes in children with bronchial asthma. Methods A total of 34 children with asthma,32 with remitting asthma,and 25 healthy children were subject to detect the expressions of CD19+CD23+and CD4+CD25+in peripheral blood lymphocytes by flow cytometer and the levels of serum IgE by chemiluminescence immunoassay. Results The expressions of CD19+CD23+in peripheral blood lymphocytes of children with asthm... |
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| Keywords: | CD19+CD23+ CD4+CD25+ |
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