卡巴胆碱对严重脓毒症患者细胞免疫功能的影响

摘要 目的研究卡巴胆碱对严重脓毒症患者CD＋14单核细胞人类白细胞抗原DR（HLA DR）的影响及临床意义。方法严重脓毒症患者100例，分为治疗组60例，对照组40例。治疗组在常规治疗基础上给予卡巴胆碱肌内注射，每次0.2 mg·kg－1，持续7 d，对照组常规治疗的同时给予安慰药。观察治疗前后CD＋14单核细胞HLA DR和T细胞亚群CD＋4、CD＋8百分率的变化。结果卡巴胆碱治疗后CD＋14单核细胞HLA DR及CD＋4、CD＋8细胞明显上升，分别为（36.30±13.14）%，（40.81±12.09）%，（31.14±3.63）%（均P＜0.05）。结论卡巴胆碱可以调节机体炎症反应状态，有助于改善严重脓毒症患者的免疫功能。

Effects of Carbachol on Cellular Immune Function in Patients with Severe Sepsis

Objective To study the clinical effects of carbachol on human leukocyte antigen DR(HLA-DR) in CD+14 monocytes from patients with severe sepsis.Methods A total of 100 cases of patients with severe sepsis were divided into two groups including the treatment group with 60 and control group with 40.The treatment group was intramuscularly administrated with carbachol at the dose of 0.2 mg·kg-1 for 7 days on the basis of conventional therapy.While the control group was given with placebo at the same time based on routine treatment.Then the proportion of HLA-DR in CD+14 monocytes and CD+4,CD+8 T cell subsets were investigated before and after treatment.Results The levels of HLA-DR in CD+14 monocytes and CD+4,CD+8 T cells were significantly increased by carbachol,which were(36.30±13.14)%,(40.81±12.09)%,(31.14±3.63)%,respectively.Conclusion Carbachol can regulate inflammatory reaction status of the body and benefit for the immune function of patients with severe sepsis.