慢性无症状HBV携带者阴虚体质与人类白细胞抗原-DRB1、DQA1基因多态性的联系 |
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引用本文: | 过建春,肖丽娜,荀运浩,王宇芳,李春青,石伟珍,施军平.慢性无症状HBV携带者阴虚体质与人类白细胞抗原-DRB1、DQA1基因多态性的联系[J].中国中西医结合杂志,2012,32(8):1038-1041. |
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作者姓名: | 过建春 肖丽娜 荀运浩 王宇芳 李春青 石伟珍 施军平 |
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作者单位: | 1.杭州市第六人民医院中西医结合科(杭州 310014); 2.浙江省桐庐县人民医院感染科(浙江 311500) |
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基金项目: | 浙江省中医药科技计划项目(No.2009WA010) |
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摘 要: | 目的 探讨慢性无症状HBV携带者(chronic asymptomatic HBV carrier,ASC)阴虚体质与人类白细胞抗原(human leukocyte antigen,HLA)-DRB1、HLA-DQA1基因多态性的内在联系。方法 将105例ASC患者进行中医体质分型及分组:阴虚质组47例和非阴虚质组58例。采用聚合酶链反应-序列特异性引物(PCR-SSP)技术测定HLA-DRB1、HLA-DQA1等位基因型。结果 阴虚质组HLA-DRB1*09、HLA-DQA1*0301的基因频率明显低于非阴虚质组(分别为12.1% vs 27.8%,19.1% vs 39.7%),差异有统计学意义(P<0.01);HLA-DRB1*11、HLA-DQA1*0501的基因频率明显高于非阴虚质组(分别为12.1% vs 4.3%,28.7% vs 9.5%),差异有统计学意义(P<0.05,P<0.01)。结论 HLA-DRB1*09和HLA-DQA1*0301可能是ASC非阴虚体质患者的分子基础;HLA-DRB1*11和HLA-DQA1*0501可能是ASC阴虚体质患者的分子基础。
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关 键 词: | 慢性无症状HBV携带者 阴虚体质 基因多态性 |
Study on the Correlation between Chronic Asymptomatic HBV Carriers of Yin Asthenia Constitution and Genotypes of HLA-DRB1 and HLA DQA1 Alleles |
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Authors: | GUO Jian-chun XIAO Li-n XIAO Li-na |
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Institution: | GUO Jian-chun,XIAO Li-na,XUN Yun-hao,et alDepartment of Integrative Medicine,Sixth People’s Hospital of Hangzhou,Hangzhou(310014) |
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Abstract: | Objective To study on the correlation between chronic asymptomatic HBV carriers(ASC) of yin asthenia constitution and genotypes of HLA-DRB1 and HLA DQA1 alleles.Methods Totally 105 ASC were assigned to two groups according to their constitutions,i.e.,the yin asthenia group(47 cases) and the non-yin asthenia group(58 cases).The genotypes of HLA-DRB1 and HLA DQA1 alleles were determined using PCR-SSP.Results The gene frequency of HLA-DRB1*09 allele and HLA-DQA1*0301 allele(being 12.1% and 19.1%) were obviously lower in the yin asthenia group than in the non-yin asthenia group(being 27.8% and 39.7%,P<0.05).The gene frequency of HLA-DRB1*11 allele and HLA-DQA1*0501 allele were obviously higher in the yin asthenia group(being 12.1% and 28.7%) than in the non-yin asthenia group(4.3% and 9.5%),showing statistical difference(P<0.05,P<0.01).Conclusions HLA-DRB1*09 allele and HLA-DQA1*0301 allele might be the molecular bases for non-yin asthenia patients with ASC.HLA-DRB1*11 allele and HLA-DQA1*0501 allele might be the molecular bases for yin asthenia patients with ASC. |
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Keywords: | chronic asymptomatic HBV carrier yin asthenia constitution polymorphism of gene |
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