| 乙酰肝素酶在子宫内膜癌组织中的表达及血管生成、浸润的关系 |
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| 引用本文： | 晁宏图,王莉,王莉英,马杰,陈红敏,刘若男. 乙酰肝素酶在子宫内膜癌组织中的表达及血管生成、浸润的关系[J]. 医学信息, 2008, 21(12) |
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| 作者姓名： | 晁宏图 王莉 王莉英 马杰 陈红敏 刘若男 |
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| 作者单位： | 河南省肿瘤医院妇瘤科,郑州450018 |
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| 摘 要： | 目的探讨乙酰肝素酶（Heparanase，Hpa）在子宫内膜癌组织中的表达及预后关系。方法采用S—P免疫组织化学法检测Hpa和CD34蛋白在子宫内膜癌组织和正常子宫内膜组织中的表达，并结合病理学分型、组织学分级、微血管密度（MVD）和临床分期探讨其意义。结果子宫内膜癌Hpa蛋白的表达显著高于正常子宫内膜（P〈0．05），子宫内膜癌组织中Hpa蛋白的表达与子宫内膜癌组织血管生成、病理分型、分期有关（P〈0．05）。结论Hpa蛋白在子宫内膜癌中呈高表达，并与子宫内膜癌血管生成、病理特征有关，检测其表达以对判断子宫内膜癌的生物学行为提供指标。
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| 关 键 词： | 子宫内膜癌 乙酰肝素酶 血管生成 |
Clinical study on the relationship between the expression of heparanase in tissue and angiogenesis metastasis of endometrial carcinoma |
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| CHAO Hong-tu,WANG Li,WANG Li-ying,et al. Clinical study on the relationship between the expression of heparanase in tissue and angiogenesis metastasis of endometrial carcinoma[J]. Medical Information, 2008, 21(12) |
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| Authors: | CHAO Hong-tu WANG Li WANG Li-ying et al |
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| Affiliation: | CHAO Hong-tu,WANG Li,WANG Li-ying,et al(Department of Gynecology Oncology,Henan Tumor Hospital,Zhengzhou 450018,Henan Province,China) |
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| Abstract: | Objective To study heparanase(Hpa) expression in endometrial cancer tissue and the relationship of Hpa expression and prognosis.Methods Immunohistochemical staining(SP method) was employed to detect the expression was of Hpa and CD34 protein in normal endometrial tissues and tumor tissues.Hpa protein expression was evalueted combining with pathological type,histologic grade,microvessel density(MVD) and clinical stage.Results The expression of Hpa protein in endometrial carcinoma tissues was significantly hi... |
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| Keywords: | endometrial carcinoma heparanase angiogenesis |
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