Parathyroid hormone related protein in hypercalcaemia of Hodgkin''s disease. |
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| Authors: | J. Bolo-Deoku S. Basu S. Lakhani F. Dunne W. A. Ratcliffe M. Clarke J. L. Barron |
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| Affiliation: | Department of Chemical Pathology & Metabolism, St Helier Hospital, Carshalton, Surrey. |
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| Abstract: | The role of parathyroid hormone related protein (PTHRP) as a humoral mediator of hypercalcaemia was investigated in a patient with lymphocyte depleted Hodgkin's disease during an episode of hypercalcaemia, using an immunohistochemical staining technique for PTHRP on the tumour tissue and an immunoradiometric (IRMA) assay for PTHRP1-86 on the patient's plasma. The plasma PTHRP was less than 0.23 pmol/l in the range found in normocalcaemic controls, and the immunohistochemical staining was not positive for protein. PTHRP did not have a role in the pathogenesis of hypercalcaemia in this patient. |
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