| 芪苈强心对阿霉素致心肌病大鼠心功能及血清因子的影响 |
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| 引用本文： | 董红科,孙洪平,姚文明,张海锋,周艳丽,李新立.芪苈强心对阿霉素致心肌病大鼠心功能及血清因子的影响[J].临床心血管病杂志,2010,26(2). |
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| 作者姓名： | 董红科 孙洪平 姚文明 张海锋 周艳丽 李新立 |
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| 作者单位： | 南京医科大学第一附属医院心内科,南京,210029 |
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| 摘 要： | 目的:初步探讨芪苈强心胶囊对阿霉素致心肌病大鼠心功能及血清因子的影响及其机制。方法:将29只SD大鼠中9只作为正常对照组,20只用作造模。造模大鼠2周内分6次腹腔注射阿霉素2.5mg/kg作为心力衰竭(心衰)模型后,分为心衰组、芪苈强心组和美托洛尔组,后2组分别服用芪苈强心胶囊生粉(1g/kg)和美托洛尔(10mg/kg)治疗6周,正常对照组和心衰组以相同体积0.9%氯化钠溶液灌胃6周。超声心动图检测各组大鼠心功能指标,ELISA法检测大鼠血清肿瘤坏死因子-α(TNF-α)和B型钠尿肽(BNP)含量,心肌组织苏木素-伊红染色病理检验。结果:心衰组较正常对照组心功能显著降低,左心室收缩末期内径(LVESD)和左心室舒张末期内径(LVEDD)显著增加(P<0.01和P<0.05),左室射血分数(LVEF)和短轴缩短率(FS)显著降低(均P<0.01),血清BNP和TNF-α水平明显升高(均P<0.01)。美托洛尔组较心衰组显著改善了大鼠的LVESD、LVEDD、LVEF和FS(均P<0.05),BNP显著低于心衰组(P<0.05)。芪苈强心组较心衰组也改善了大鼠LVEF和FS(均P<0.05),显著降低心衰大鼠血...
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| 关 键 词： | 心肌疾病 芪苈强心胶囊 美托洛尔 B型钠尿肽 肿瘤坏死因子-α |
Effect of Qiliqiangxin on heart function and serum factors in a rat model of cardiomyopathy induced by adriamycin |
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| DONG Hongke,SUN Hongping,YAO Wenming,ZHANG Haifeng,ZHOU Yanli,LI Xinli.Effect of Qiliqiangxin on heart function and serum factors in a rat model of cardiomyopathy induced by adriamycin[J].Journal of Clinical Cardiology,2010,26(2). |
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| Authors: | DONG Hongke SUN Hongping YAO Wenming ZHANG Haifeng ZHOU Yanli LI Xinli |
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| Institution: | Department of Cardiology/a>;the First Affiliated Hospital/a>;Nanjing Medical University/a>;Nanjing/a>;210029/a>;China |
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| Abstract: | Objective:To investigate the effects of Qiliqiangxin capsule on heart function and serum factors in a rat model of cardiomyopathy induced by adriamycin.Method:The SD rats were randomly divided into two groups:normal control group and model building group. Rats in model building group were injected adriamycin (2.5 mg/kg) intravenously 6 times for 2 weeks. Rats surviving in model building group were randomly divided into three groups:heart failure group,Qiliqiangxin group and metoprolol group.Rats in Qiliqian... |
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| Keywords: | cardiomyopathy qiliqiangxin capsule metoprolol B-type natriuretic peptide |
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