| 卷柏水煎液对小鼠心肌缺血再灌注损伤的影响 |
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| 引用本文： | 李远发,汪璐,龚平,黎清波,胡敏,严晓红.卷柏水煎液对小鼠心肌缺血再灌注损伤的影响[J].武汉大学学报(医学版),2011,32(4):429-431,501,封2. |
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| 作者姓名： | 李远发 汪璐 龚平 黎清波 胡敏 严晓红 |
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| 作者单位： | 武汉大学医学院生理学系,湖北武汉,430071 |
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| 基金项目： | 国家自然科学基金资助项目(编号:31071005) |
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| 摘 要： | 目的:探讨卷柏水煎液对心肌缺血再灌注损伤(MI/R)的影响及作用机制.方法:KM雄性小鼠随机分为正常对照组、MI/R损伤模型组、卷柏水煎液低剂量+MI/R组、卷柏水煎液高剂量+MI/R组,卷柏水煎液灌胃给药5 d后,腹腔注射垂体后叶素和硝酸甘油复制心肌缺血再灌注模型,同时记录不同时点的肢体Ⅱ导联心电图,连续观察80 m...
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| 关 键 词： | 卷柏水煎液 缺血再灌注损伤 心肌 小鼠 |
Effects of Selaginellae on Mouse Myocardial Ischemic-Reperfusion Injury |
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| LI Yuanfa,WANG Lu,GONG Ping,LI Qingbo,HU Min,YAN Xiaohong.Effects of Selaginellae on Mouse Myocardial Ischemic-Reperfusion Injury[J].Medical Journal of Wuhan University,2011,32(4):429-431,501,封2. |
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| Authors: | LI Yuanfa WANG Lu GONG Ping LI Qingbo HU Min YAN Xiaohong |
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| Institution: | LI Yuanfa,WANG Lu,GONG Ping,LI Qingbo,HU Min,YAN Xiaohong Dept.of Physiology,School of Medicine,Wuhan University,Wuhan 430071,China |
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| Abstract: | Objective:To investigate the effect of selaginellae on myocardial ischemic-reperfusion injury in mice and its mechanism.Methods:Forty male Kunming mice were randomly divided into four groups:normal group,myocardial ischemic-reperfusion injury(MI/R) model group,low dose selaginellae(0.02 ml/g apozem,once a day for 5 days) + MI/R group,and high dose selaginellae(0.02 ml/g apozem,twice a day for 5 days) + MI/R group.MI/R model of mice was established by intraperitoneal injection of pituitrin(20 U/kg) and follo... |
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| Keywords: | Apozem of Selaginellae Ischemic-Reperfusion Injury Myocardium Mice |
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