脑卒中后抑郁与血清超敏C反应蛋白的关系

目的:探讨脑卒中后抑郁患者与超敏C反应蛋白(hs-CRP)的关系.方法:选择144例急性脑卒中的患者,应用ZUNG抑郁自评量表进行初步筛选,脑卒中后抑郁的诊断标准按照美国精神障碍诊断与统计手册第4版(DSM-Ⅳ)进行,并采用24项汉密尔顿抑郁量表分为卒中抑郁组(轻度、中度及重度抑郁)、卒中无抑郁组,并设正常对照组.分别...

Relationship Between Serum Level of C-Reactive Protein and Post-Stroke Depression

Objective: To explore the relationship between the serum level of C-reactive protein and the post-stroke depression(PSD).Methods: One hundred and forty four patients with acute stroke were screened for the diagnosis of PSD according to DSM-Ⅳ.All patients assessed with ZUNG Self-Rating Depression Scale as Preliminary screening,and PSD group were sub-divided into three groups as mild,middle,and severe PSD groups according to the 24-item Hamilton Depression Rating Scales(HAMD).The serum levels of C-reactive protein were dynamically tested after one day,one week,and two weeks after stroke in all patients.Results: The incidence rate of PSD was 36.11%.The hs-CRP levels in stroke groups decreased gradually after one day,one week and two weeks respectively after stroke.The serum levels of hs-CRP were significantly different in a depression-degree-dependent manner among PSD,non-PSD,and control groups,and among PSD groups at different degrees(all P<0.01).The serum levels of hs-CRP in PSD group had a positive correlation to the average scores of HAMD and ZUNG in one day,one week and two weeks after stroke(P<0.0001).Conclusion: The change of serum levels of hs-CRP might exist in patients with PSD,and it suggests that PSD might be early diagnosed by dynamically testing the serum levels of hs-CRP.