| 网孔型纳米羟基磷灰石/聚酰胺66复合生物活性材料治疗早期股骨头缺血坏死的实验研究 |
| |
| 引用本文： | 陈诚,梁熙,黄伟,胡宁,阳明明,尹世杰.网孔型纳米羟基磷灰石/聚酰胺66复合生物活性材料治疗早期股骨头缺血坏死的实验研究[J].西部医学,2011,23(8):1421-1424. |
| |
| 作者姓名： | 陈诚 梁熙 黄伟 胡宁 阳明明 尹世杰 |
| |
| 作者单位： | 重庆医科大学附属第一医院骨科,重庆,400000 |
| |
| 基金项目： | 国家"863"项目，重庆市自然科学基金资助 |
| |
| 摘 要： | 目的观察网孔型纳米羟基磷灰石/聚酰胺66（n-HA/PA66）支撑棒及其复合血管内皮细胞生长因子（VEGF）后治疗兔股骨头早期缺血性坏死的实验效果。方法将n-HA/PA66支撑棒及VEGF缓释微球植入兔早期股骨头缺血坏死模型,术后3、6、12周行影像学及组织切片观察。结果植入n-HA/PA66支撑棒的实验兔未发现股骨头塌陷的影像学征象且骨质修复良好,其组织学检查显示新生骨长入n-HA/PA66,VEGF的持续缓释能促进骨长入及血管重建。结论网孔型n-HA/PA66支撑棒能有效预防早期股骨头缺血坏死的股骨头塌陷,VEGF缓释微球能加快骨修复过程。
|
| 关 键 词： | 羟基磷灰石/聚酰胺66 股骨头缺血坏死 骨修复 动物实验 |
Nano-hydroxyapatile/polyamide 66 biocomposites (n-HA/PA66) for treating early avascular necrosis of femoral head |
| |
| CHEN Cheng,LIANG Xi,HUANG Wei,et al.Nano-hydroxyapatile/polyamide 66 biocomposites (n-HA/PA66) for treating early avascular necrosis of femoral head[J].Medical Journal of West China,2011,23(8):1421-1424. |
| |
| Authors: | CHEN Cheng LIANG Xi HUANG Wei |
| |
| Institution: | CHEN Cheng,LIANG Xi,HUANG Wei,et al(Department of Orthopedics,The First Affiliated Hospital of Chongqing Medical University,Chongqing Medical University,Chongqing 400000) |
| |
| Abstract: | Objective To observe the effect of porous n-HA/PA66 rods and vascular endothelial growth factor(VEGF) for treatment of early stage avascular necrosis of femoral head in rabbits.Methods The n-HA/PA66 supporting stick and VEGF microcapsul were implanted into the rabbit models of vascular necrosis of femoral head.Results were evaluated by radiograph and histology at the end of 3rd,6th and 12th week after operation.Results In the group B and C,no collapse of femoral head was observed.The New bone formation and ... |
| |
| Keywords: | Nano-hydroxyapatite/polyamide 66 Avascular necrosis of femoral head VEGF Zoopery Support |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
