Permeability of porcine nasal mucosa correlated with human nasal absorption. |
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| Authors: | Cecilia Wadell Erik Bj?rk Ola Camber |
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| Affiliation: | 1. Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia;2. Laboratorio de Virologia Aplicada, Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina, Campus Universitário, Trindade, Florianópolis-SC 88040-900, Brazil;1. Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark;2. Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark;3. Biologics and Pharmaceutical Science, H. Lundbeck A/S, Valby, Denmark;4. Fertin Pharma A/S, Vejle, Denmark;1. Department of Physiological Sciences, Piracicaba Dental School, University of Campinas — UNICAMP, Piracicaba, São Paulo, Brazil;2. Department of Morphology, Piracicaba Dental School, University of Campinas — UNICAMP, Piracicaba, São Paulo, Brazil;3. Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas — UNICAMP, Campinas, São Paulo, Brazil;4. School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo — USP, Ribeirão Preto, São Paulo, Brazil |
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| Abstract: | ![]()
The Ussing chamber diffusion system was used as a model to study the apparent permeability across porcine nasal mucosa of eight drugs and molecules with different physicochemical characteristics, namely insulin, lidocaine, nicotine, PEG 4000, propranolol, sumatriptan, melagatran and an amino diether. A weak correlation was found between the apparent permeability coefficients and the corresponding literature data on the fraction absorbed after nasal administration in humans. In the case of passively transported drugs, a closer correlation was found than for the substances where other mechanisms such as carrier-mediated transport or possible efflux were involved. Factors influencing the correlation between in vitro and in vivo data are discussed and the importance of electrophysiological control of the viability status of the excised mucosa is emphasised. Although caution has to be exercised in view of the limitations of the in vitro system, it seems to be a useful tool when evaluating different factors influencing permeability of nasal mucosa. |
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