Bombesin inhibits growth hormone response to insulin-induced hypoglycemia in humans |
| |
| Authors: | Carmelo Scarpignato Franco Tirelli Antonio E. Pontiroli |
| |
| Affiliation: | 1. Laboratory of Clinical Pharmacology, Institute of Pharmacology, University of Parma University of Milan, S. Raffaele Hospital, Milano-Segrate Italy;2. Department of Biomedical Sciences, University of Milan, S. Raffaele Hospital, Milano-Segrate Italy |
| |
| Abstract: | ![]()
Intravenous administration of bombesin (5 ng/kg/min X 2.5 h) significantly reduced growth hormone (GH) response to insulin-induced (0.15 U/kg, i.v.) hypoglycemia in 8 male volunteers without affecting its basal plasma levels. These data, together with the presence of bombesin-like immunoreactivity in the human brain, suggest that--as in experimental animals--this neurogastrointestinal peptide may be of physiological significance in the control of GH secretion also in man. |
| |
| Keywords: | bombesin growth hormone insulin hypoglycemia |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
