Regulation of glucose transporter-4 intervention with S. saman leaves extract in streptozotocin-induced diabetic rats |
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| Institution: | 1. Department of Bio-Medical Sciences, School of Biosciences and Technology, VIT, Vellore, Tamil Nadu, India;2. Department of Biotechnology, College of Science and Humanities, SRM Institute of Science and Technology, Ramapuram, Chennai 600087, India;1. The Israel Center for Disease Control, Israel Ministry of Health, Tel Hashomer, Israel;2. Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;3. School of Public Health, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel;4. Stroke and Cognition Institute, Rambam Health Care Campus, Haifa, Israel;5. Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel;1. Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran;3. Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran;1. Department of Pharmacy, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China;2. School of Pharmacy, Chongqing Medical University, Chongqing, China;1. Steno Diabetes Center Copenhagen, Denmark;2. Orthopedic Department, North Zealand Hospital, Hillerød Hospital, Denmark;3. Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark |
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| Abstract: | Diabetes mellitus is the leading disorder and affects more than millions of people worldwide. Nowadays, the usage of herbal drugs is said to control adiposity and hyperglycemia. The current research investigated the anti-adiposity and antidiabetic activity of S. saman leaf extract and bioactive compounds. Therefore, the results lower the sugar absorption into the blood and reveal the extract's antidiabetic properties. STZ-induced diabetic rats, Samanea saman methanolic extract show improvement in the parameters like fasting blood glucose levels, body weight, other biochemical parameters supported by the histopathological analysis, and an increase in serum levels in the experimental groups. The antioxidant plays a vital role by increasing SOD and catalase activity levels and decreasing lipid peroxidation levels. The methanolic extract protects the tissue from oxidation stress, which is responsible for the glycemic properties. According to the findings, diabetic-treated rats had overnight blood glucose levels lower and near standard biochemical markers. Histopathology of the liver, pancreas, kidneys, and adipose tissues supported the pharmacological observations.Further, we screened and documented S. saman extract used for in vitro and in vivo methods. In terms of effectiveness, the crude extracts exhibit 0.8-fold GLUT4 down-regulation. Consequently, this result contributes to clinical trials and develops antidiabetic therapy as a substitute for synthetic pharmaceuticals. |
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