Gender difference in association between diabetes mellitus and all-cause mortality in atrial fibrillation patients |
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| Institution: | 1. Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, People''s Republic of China;2. State Key Laboratory of Cardiovascular Disease, Emergency and Critical Care Centre of Cardiovascular Department, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, People''s Republic of China;1. Departamento de Nutrición, Diabetes y Metabolismo, Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Católica de Chile, Diagonal Paraguay 362, Santiago, Chile;2. Servicio de Farmacia, Hospital Clínico de la Pontificia Universidad Católica de Chile, Marcoleta 367, Santiago, Santiago, Chile;3. Escuela de Química y Farmacia, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Av. Vicuña Mackenna 4860, Macul, Chile;4. Complejo Asistencial Dr. Sótero del Río, Avenida Concha y Toro 3459, Puente Alto, Santiago, Chile;5. División de Pediatría-Programa Diabetes de niños y adolescentes, Departamento de Nutrición, Diabetes y Metabolismo, Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Católica de Chile, Diagonal Paraguay 362, Santiago, Chile;1. Department of Pediatrics, College of Medicine, Qassim University, Qassim 51452, Saudi Arabia;2. Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA 70118, USA;3. Children''s Hospital of New Orleans, New Orleans, LA 70118, USA;1. Complication Research, Steno Diabetes Center Copenhagen, Capital Region, Denmark;2. Clinical Epidemiology, Steno Diabetes Center Copenhagen, Capital Region, Denmark;3. Department of Clinical Medicine, University of Copenhagen, Capital Region, Denmark;4. Department of Public Health, University of Copenhagen, Capital Region, Denmark;5. Department of Medicine, University of Toronto, Division of Nephrology, Toronto, Ontario, Canada;6. Toronto General Hospital Research Institute, Toronto, Ontario, Canada;1. Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Republic of Korea;2. Department of Physiology, Keimyung University School of Medicine, Daegu, Republic of Korea;1. The Gastroenterology Department of the First Hospital of Nanning, Nanning, Guangxi Province 530022, PR China;2. The Ultrasonography of Maternal and Children Health Hospital of Guangxi, Guangxi Province 530022, PR China |
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| Abstract: | ObjectiveThere may be gender difference in correlation of diabetes mellitus (DM) and cardiovascular events. We attempt to investigate whether there is gender-heterogeneity in one-year outcomes of atrial fibrillation (AF) patients with DM or not.MethodsPatients who were diagnosed with AF admitted to the emergency departments in the Chinese AF Multicenter Registry study were enrolled. Basic demographics information, initial Blood Pressure and heart rate, medical histories, and treatments of each patient were collected. Follow-up was carried out with a mean duration of one year. The primary endpoint was all-cause mortality and systemic embolism.ResultsA total of 2016 patients were selected from September 2008 and April 2011. All-cause mortality was significantly higher in male AF patients with DM than those without (21.8 % & 13.6 %, P = 0.014). Cox regression analysis showed that there was an interaction between gender and DM for one-year all-cause mortality (P = 0.049). DM was significantly associated with one-year all-cause mortality regardless of univariate analysis (HR = 1.436, 95%CI:1.079–1.911, P = 0.013) or multivariate analysis (HR = 1.418, 95%CI: 1.059–1.899, P = 0.019). For male patients with AF, DM was significantly associated with one-year all-cause mortality (P = 0.048), but not for female patients with AF (P = 0.362).ConclusionDM was independently associated with one-year all-cause mortality in the entire cohort of AF patients. This association was found mainly in male patients with AF, but not in female patients. DM management programs may need to reflect gender difference. |
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