Pediatric intestinal transplantation |
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| Affiliation: | 1. Department of Pediatric Colorectal and Pelvic Reconstructive Surgery, Nationwide Children''s Hospital, Columbus, OH, USA;2. Division of Pediatric General and Thoracic Surgery, Cincinnati Children''s Hospital Medical Center, Cincinnati, OH, USA;1. Division of Neonatology and Pulmonary Biology, Cincinnati Children''s Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, MLC 7009, United States;2. Division of Nephrology and Hypertension, Cincinnati Children''s Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, United States;3. Division of Pediatric General and Thoracic Surgery and Center for Fetal Care, Cincinnati Children''s Hospital Medical Center and Department of Surgery, University of Cincinnati College of Medicine, United States;4. Division of Pediatric Urology, Cincinnati Children''s Hospital Medical Center and Department of Surgery, University of Cincinnati College of Medicine, United States;1. Heart Institute;2. Division of Pulmonary Medicine Cincinnati Children''s Hospital Medical Center, Cincinnati, OH;3. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH;4. Division of Critical Care Medicine, Boston Children''s Hospital, Boston, MA;5. of Pediatrics, Harvard Medical School, Boston, MA;6. Children''s Healthcare of Atlanta, Atlanta, GA |
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| Abstract: | Advancements in donor management, organ preservation and operative techniques, as well as immunosuppressive therapies, have provided children with intestinal failure and its complications a chance not only for enteral autonomy but also long-term survival through intestinal transplantation (ITx). First described in the 1960’s, experience has grown in managing these complex patients both pre- and post-transplant. The goals of this review are to provide a brief history of intestinal transplantation and intestinal rehabilitation in pediatric patients, followed by focused discussions of the indications for ITx, induction and maintenance immunosuppression therapies, common post-operative complications, and outcomes/quality of life post-transplant. |
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