Survivin在上皮性卵巢癌中的表达及意义

目的:检测survivin在上皮性卵巢癌组织中的表达,探讨survivin的表达与上皮性卵巢癌临床病理特征的关系。方法:应用免疫组织化学链霉亲和素-生物素-过氧化物霉复合物(SABC)方法,检测40例上皮性卵巢癌组织,20例良性上皮性卵巢肿瘤组织,20例正常卵巢组织中survivin的表达情况。结果:上皮性卵巢癌组织中survivin的阳性表达率为77.5%,高于良性上皮性卵巢肿瘤组织及正常卵巢组织的10%～0%(P<0.05),与组织学类型无相关性(P>0.05),与临床分期、组织学分级及淋巴结转移有关(P<0.05)。结论:survivin在上皮性卵巢癌组织中皆呈高表达,提示survivin可能与上皮性卵巢癌的浸润、转移有关。

Expression of survivin in epithelial ovarian cancer and its significance

Objective:To study the relationship between the expression of survivin with the histological type,grade,surgical stage and lymphatic metastasis in epithelial ovarian cancer.Methods:The expression of survivin in 40 case of epithelial ovarian cancers,20 case of benign epithelial ovarian tumors and 20 case of normal ovarian tissues were detected by immunohistochemistry streptomycin-avidin-biotin-peroxidase complex(SABC)method.Results:Survivin was expressed 77.5%(31/40)in epithelial ovarian cancers,10%(2/20)in benign epithelial ovarian tumors and 0%(0/20)in normal ovarian tissues.The expression of survivin was significantly higher in epithelial ovarian cancers than that in benign epithelial ovarian tumors and normal ovarian tissues(P<0.01).The overrexpression of survivin was related to the surgical stage histological grade and lymphatic metastasis,no relationship with the histological type(P>0.05).Conclusion:The overexpression of survivin maybe related with the invasion and metastasis in epithelial ovarian cancer.