肾综合征出血热原发性休克治疗的临床研究

目的比较两种方法治疗肾综合征出血热(HFRS)原发性休克患者的疗效。方法1980年1月至1987年12月用旧法治疗1195例,给予快速晶体液扩容等治疗。1988年1月至2002年12月用新法治疗608例,给予晶胶结合扩容、改善微循环和纳洛酮等综合治疗。结果新法组与旧法组相比,治疗后1h、2h休克纠正率分别升高23. 52% (p<0 01 )和25 03% (p<0 01);难治性休克降低3 05% (P<0 01);超越少尿期升高为4 46% (P<0 05);病死率降低3 65% (P<0 05)。结论新法组疗效明显优于旧法组。

Clinical studies on treatment of the primary shock with HFRS

Objective To compare the efficacy on treatment of the primary shock with two methods. Methods From January 1980 to December 1987,1195 cases were treated with old method ,quick venoclysis of crystalloid fluid. From January 1988 to December 2002, 608 cases were treated with new method ,venoclysis of crystalloid and colloid fluid, improvement of microcirculation and naloxone,et al. Results As compared with the old group, the new group showed that the rate of the case to free from shock had inreased by 25.32%(p<0.01) and 25.03% (p<0.01) after anti-shock treating for 1 hour and 2 hours,respectively, the rate of the cases with rebellious shock had decreased by 3.05% (p<0.01); the rate of the cases who did not undergo oliguric stage had incresed by 4.46% (p<0.05); the fatality rate had decresed by 3.65% (p<0.05). Conclusion There is significant difference on the therapeutic efficacy, the new method is evidently more efficient.