|
|||||
|
|
| COX-2和VEGF在食管鳞癌中的表达及其与淋巴结转移的关系 | |
| 引用本文： | 王丹云,杨长征,陈志涛,张勃,贾瑞. COX-2和VEGF在食管鳞癌中的表达及其与淋巴结转移的关系[J]. 中华肿瘤防治杂志, 2006, 13(9): 689-691 |
| 作者姓名： | 王丹云 杨长征 陈志涛 张勃 贾瑞 |
| 作者单位： | 山东大学医学院病理教研室,山东,济南,250013;济南市中心医院胸外科,山东,济南,250013 |
| 摘 要： | 目的:探讨血管内皮生长因子(VEGF)和环氧化酶-2(COX-2)蛋白在食管鳞癌(ESCC)中的表达情况及其与淋巴结转移的关系。方法:应用SP法对60例ESCC手术病理标本进行COX-2和VEGF蛋白表达检测。结果:COX-2和VEGF在ESCC中的表达率分别为85.0%(51/60)和53.3%(32/60)。有淋巴结转移组COX-2和VEGF的表达水平均高于未转移组。COX-2和VEGF蛋白的表达呈明显的正相关,r=0·5202,P<0·01。结论:ESCC中COX-2和VEGF的高表达与ESCC的发生、发展及淋巴结转移有重要关系。 |
| 关 键 词： | 食管肿瘤 环氧化酶-2 血管内皮生长因子 免疫组织化学 |
| 文章编号： | 1673-5269（2006）09-0689-03 |
| 收稿时间： | 2006-02-27 |
| 修稿时间： | 2006-03-20 |
Relationship between expressions of COX-2 and VEGF protein and lymph node metastasis in ESCC |
|
| WANG Dan-yun,YANG Chang-zheng,CHEN Zhi-tao,ZHANG Bo,JIA Rui. Relationship between expressions of COX-2 and VEGF protein and lymph node metastasis in ESCC[J]. Chinese Journal of Cancer Prevention and Treatment, 2006, 13(9): 689-691 | |
| Authors: | WANG Dan-yun YANG Chang-zheng CHEN Zhi-tao ZHANG Bo JIA Rui |
| Abstract: | OBJECTIVE:To explore the relationship between high expressions of COX-2 and VEGF protein and lymph node metastasis in ESCC. METHODS:The immunohistochemistry method was applied to determine the expressions of COX-2 and VEGF in 60 surgically resected human esophageal cancer specimens. RESULTS:The positive rates of COX-2 and VEGF in ESCC were 85.0%(51/60) and 53.3%(32/60) respectively. The expression rates of COX-2 and VEGF were higher in the group of lymph node metastasis than those in the group without lymph node metastasis. COX-2 expression was significantly correlated with VEGF expression,r=0.520 2,P<0.01.CONCLUSIONS:The over-expressions of COX-2 and VEGF may play a crucial role in the carcinogenesis and development of ESCC, and it enhances lymphatic metastasis in patients with ESCC. |
| Keywords: | esophagea neoplasms cyclooxygenase-2 vascular endothelial growth factor immunohistochemistry |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |