银杏叶注射液治疗晚期肺癌患者血液高凝状态的疗效观察

目的 观察银杏叶注射液对于肺癌患者血液高凝状态的疗效及其安全性。方法 选取2010 年10 月至2014 年10月河北大学附属医院收治 109 例晚期肺癌患者作为研究对象，随机分成治疗组（50 例）和对照组（59 例）。对照组仅行全身化疗，治疗组予以全身化疗联合应用银杏叶注射液，7 d 为 1 个疗程，治疗 2 个疗程后对比 2 组疗效及 Fib（血浆纤维蛋白原）、D-D（D- 二聚体）水平。结果 治疗组的改善率为 81.36%（48/59） ，对照组的为 26%（13/50）；治疗组无效率为8.47%（5/59） ，对照组的为32%（16/50）；治疗组稳定率为10.17%（6/59） ，对照组的为42%（21/50）（均P<0.05）。治疗组治疗前和对照组治疗前Fib、D-D 水平差异无统计学意义（P>0.05），而治疗后的 Fib、D-D 均显著低于对照组治疗后的 Fib 、D-D，差异有统计学意义（P<0.05）。治疗组与对照组 Fib 和 D-D 水平治疗前后差值比较（P<0.05），治疗组疗效优于对照组。治疗组未出现明显不良反应。结论 银杏叶注射液能改善肺癌患者血液高凝状态，疗效及安全性均较好。

Clinical observation of Ginkgo biloba injection in treating hypercoagulable states of patients with advanced lung cancer

Objective To observe the efficacy and safety of Ginkgo biloba injection in treating blood hypercoagulable state of patients with advanced lung cancer. Methods 109 cases with advanced lung cancer in the Affiliated Hospital of Hebei University were divided into experimental group (50 cases) and control group (59 cases) between 2010.10 to 2014.10. The patients of the control group were treated only with systemic chemotherapy, those of the experimental group were also treated with chemotherapy combined with Ginkgo biloba injection. Fib, D-D levels and curative effects were compared after 2 courses of treatment, which one period of treatment was 7 days. Results The improvement rate of experimental group was 81.36% (48/59), and 26% (13/50) in the control group. Inefficiency in the experimental group and control group was 8.47% (5/59) and 32% (16/50), and the stability factor was 10.17% (6/59) and 42% (21/50) ( both P<0.05). Comparing two groups, the Fib and D-D levels did not have any significant difference before treatment (P>0.05). However, the two levels of the experimental group were lower than those of the control group after treatment, and the difference was significant (P<0.05). The difference about the Fib and D-D levels before and after treatment between the experimental group and the control group was significant (P<0.05), showing that the curative effect of the experimental group was better than that of the control group.Experimental group did not appear obvious adverse reactions. Conclusion Ginkgo biloba injection can improve blood hypercoagulable state of patients with lung cancer, which is effective and safety.