| 大黄酚的抗衰老作用 |
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| 引用本文： | 张丹参,张力,薛贵平,王树.大黄酚的抗衰老作用[J].中国医院药学杂志,2005,25(1):15-17. |
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| 作者姓名： | 张丹参 张力 薛贵平 王树 |
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| 作者单位： | 北方学院,河北,张家口,075000 |
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| 摘 要： | 目的:观察大黄酚对过氧化脂质(LPO)及脑胆碱酯酶(AChE)活性的影响。方法:采用分光光度法,体外实验测定大鼠肝、 脑组织中丙二醛(MDA)含量,体外实验及颈管内(icv)给药测定小鼠脑组织中AChE活性。结果:大黄酚可显著抑制大鼠肝、脑 LPO的生成,减少组织MDA含量,在体内、外均可显著抑制小鼠脑AChE活性,且有剂量相关性。结论:大黄酚具有抗衰老作用, 其作用机制与抑制LPO和AChE活性有关。
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| 关 键 词： | 大黄酚 抗衰老 过氧化脂质 丙二醛 胆碱脂酶 |
| 文章编号： | 1001-5213(2005)01-0015-03 |
| 修稿时间： | 2004年4月19日 |
Study on antisenility effect of chrysophanol |
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| ZHANG Dan-shen,ZHANG Li,XUE Gui-ping,WANG Shu.Study on antisenility effect of chrysophanol[J].Chinese Journal of Hospital Pharmacy,2005,25(1):15-17. |
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| Authors: | ZHANG Dan-shen ZHANG Li XUE Gui-ping WANG Shu |
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| Abstract: | OBJECTIVE To observe the influence of chrysophanol on the content of lipoperoxide(LPO) in liver and brain of rat and the activity of acetylcholinesterase(AChE) in brain of mice.METHODS Using spectrophotometry,the effect of chrysophanol on the content of MDA in liv er and brain of rat,and the activity of AChE in mice brain,in vitro tes t or icv,were observed. RESULTS Chrysophanol could inhibit significantly LPO formation and decrease the content of MDA in liver and brain of rat. In vitro test and icv chrysophanol could decrease the AChE activity in brai n of mice. The effect might be related to the dose of chrysophanol. CONCLUSION Chrysophanol has the effects of antisenility in the animal study. |
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| Keywords: | chrysophanol antisenility lipoperoxide (LPO) melondialdehyde (MDA) acetylcho linesterase (AChE) |
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