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| 莪术醇修饰的肿瘤疫苗抗MFC效应的研究 | |
| 引用本文： | 徐立春,边可君,卜平,许祥裕,周娟,刘志敏,孙振华,陈平. 莪术醇修饰的肿瘤疫苗抗MFC效应的研究[J]. 现代肿瘤医学, 2006, 14(11): 1357-1359 |
| 作者姓名： | 徐立春 边可君 卜平 许祥裕 周娟 刘志敏 孙振华 陈平 |
| 作者单位： | 1. 扬州大学中西医结合研究所,江苏,扬州,225001 2. 南京军事医学研究所,江苏,南京,210029 3. 江苏省苏北人民医院,江苏,扬州,225001 |
| 基金项目： | 江苏省卫生厅重大科研课题资助项目(编号K200511) |
| 摘 要： | 目的:研究中药莪术提取的有效成分-莪术醇生物修饰构建的肿瘤细胞疫苗对荷瘤(MFC)小鼠的免疫功能变化及治疗效应。方法:用现代生物学技术修饰构建瘤苗,观察莪术醇-MFC细胞瘤苗体外激活脾淋巴细胞的能力,体内成瘤性变化及作为瘤苗对荷瘤胃癌的小鼠治疗作用。结果:莪术醇-MFC细胞瘤苗在体外能有效诱导免疫细胞活化增殖和特异性CTL活性的产生,体内的成瘤能力明显下降,免疫接种瘤苗后对荷瘤鼠胃癌小鼠有较好的治疗效果。结论:莪术醇修饰的肿瘤细胞瘤苗能明显增强其免疫原性、对荷瘤胃癌小鼠有较好的治疗效应。 |
| 关 键 词： | 莪术醇 MFC 生物构建疫苗 治疗胃癌效应 |
| 文章编号： | 1672-4992-（2006）11-1357-03 |
| 收稿时间： | 2006-02-27 |
| 修稿时间： | 2006-02-27 |
Anti-MFC effect of curcumol-modified tumor cells vaccine |
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| XU Li-chun,BIAN Ke-jun,BO Ping,XU Xiang-yu,ZHOU Jian,LIU Zhi-min,SUN Zhen-hua,CHEN Ping. Anti-MFC effect of curcumol-modified tumor cells vaccine[J]. Journal of Modern Oncology, 2006, 14(11): 1357-1359 | |
| Authors: | XU Li-chun BIAN Ke-jun BO Ping XU Xiang-yu ZHOU Jian LIU Zhi-min SUN Zhen-hua CHEN Ping |
| Abstract: | Objective:To explore the anti-MFC effect on gastric cancer (MFC)by tumor cell vaccine modified with Curcumol. Methods: After the MFC cell line was established by modified of curcumol ,the capacity of curcumol -MFC cells to activate spleen lymphocytes was determined in vitro and the therapeutic effects of the cells being used as vaccine on gastric cancer were investigated in mice .Results: Curcumol modified MFC vaccine effectively induced the activation and proliferation of the spleen cell and the production of CTL cytotoxictity in vitro .The tumorogenicity of curcumol -MFC cells was remarkably low in vivo .The curcumol-MFC cells could exert good effection gastric cancer in the mice .Conclusion: The immuogenicity is increased by curcumol modified MFC tumor cells and can effectively inhibit the growth of MFC in the host . |
| Keywords: | curcumol MFC modified tumor vaccine gastric cancer |
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