滁州市2004~2005年C群流脑流行特征分析

目的研究滁州市C群流脑的流行特征与控制措施,为今后C群流脑防控工作提供科学依据。方法对2004~2005年度流脑个案调查、实验室检测结果进行分析。结果28例流脑患者中检出5例C群Nm,病例的密切接触者中检出4株C群Nm;在地区分布中,南谯区乌衣镇中学发生5例C群流脑为局部爆发,其余为散发病例;病倒中学生占71.42%,10~20岁年龄组占71.42%;有A群流脑疫苗免疫史占82.14%,有5例流脑A C二价疫苗免疫失败。结论C群流脑病例来势凶猛,病程进展快,病死率高;接种A群流脑疫苗不能阻止C群流脑流行;为防止发病控制疫情扩散,应对20岁以下人群和在校的大、中专学生等易感群体提供免疫保护。

Clinical Features and Epidemiological Characteristics of Epidemic Cerebrospinal Meningitis Caused by Serogroup C in Chuzhou City

Objective This paper studyed the epidemiological characteristics and the control measures of the epidemic cerebrospinal meningitis by serogroup C in Chuzhou city so as to provide science basis for the epidemic cerebrospinal meningitis control.Methods Data of case investigation and laboratory detection in 2004-2005 were analyzed.Results 5 strains of serogroup C Nm were isolated from 5 of 28 cases and 4 strains of serogroup C Nm were isolated from their close contancts.Only one outbreak occurred in Wuyi middle school of Nanqiao district.The rest cases occurred sporadically.The student cases,aged 10-20,accounted for 71.42%.82.14% cases were vaccinated with serogroup A vaccine.Conclusions The immunity induced by serogroup A vaccine could not prevent serogroup C Nm infection.We should provide the immunity protection to the population under 20 or school students.