| 乳香的化学成分 |
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| 引用本文： | 李福双,颜冬兰,刘让如,徐康平,谭桂山.乳香的化学成分[J].中国天然药物,2010(1):25-27. |
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| 作者姓名： | 李福双 颜冬兰 刘让如 徐康平 谭桂山 |
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| 作者单位： | 中南大学药学院;中南大学附属湘雅医院; |
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| 基金项目： | supported by Provincial Science and Technology Plan of Hunan (No.06sk3001); Precision Equipment and Apparatus Foundation of Central South University (No.ZKJ2009019)~~ |
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| 摘 要： | 目的：研究乳香提取物的化学成分。方法：超临界萃取乳香有效部位，采用硅胶柱层析，制备薄层层析等色谱方法，分离乳香提取物的化学成分。采用四甲基偶氮唑蓝（MTT）法观察化合物3、4对肿瘤细胞的抑制增殖作用。结果：分离得到9个化合物，经波谱方法鉴定为西松烯A（1），verticilla-4（20），7，11-triene（2），11-羰基-β-乙酰乳香酸（3），3-羰基-甘遂烷名，24-二烯．21-酸（4），花生酸（5），棕榈酸（6），硬脂酸（7），1，2-二羟基十九酮-3（8），单棕桐酸甘油酯（9）。结论：化合物7～9为首次从该属植物中分离得到。化合物3对lgel-7402细胞有抑制增值作用，化合物4对MCF．7，SMMC．7721，K562Hela细胞右抑制增殖作用．
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| 关 键 词： | 乳香 化学成分 抗肿瘤 |
Chemical Constituents of Boswellia carterii(Frankincense) |
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| Li Fu-Shuang,YAN Dong-Lan,LIU Rang-Ru,XU Kang-Ping,TAN Gui-Shan, School of Pharmaceutical Sciences,Central South University,Changsha ,Xiangya Hospital Affiliated to Central South University,Changsha ,China.Chemical Constituents of Boswellia carterii(Frankincense)[J].Chinese JOurnal of Natural Medicines,2010(1):25-27. |
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| Authors: | Li Fu-Shuang YAN Dong-Lan LIU Rang-Ru XU Kang-Ping TAN Gui-Shan School of Pharmaceutical Sciences Central South University Changsha Xiangya Hospital Affiliated to Central South University Changsha China |
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| Institution: | Li Fu-Shuang1,YAN Dong-Lan1,LIU Rang-Ru1,XU Kang-Ping1,TAN Gui-Shan1,2 1School of Pharmaceutical Sciences,Central South University,Changsha 410013,2Xiangya Hospital Affiliated to Central South University,Changsha 410008,China |
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| Abstract: | AIM： To investigate the chemical constituents of Boswellia carterii Birdwood （Frankincense） METHODS： The constituents were isolated and purified by silca-gel column chromatorgraphy and preparative TLC. The anti-tumor experiment in vitro, the MTT. was used to screen compounds 3, 4. RESULTS： Nine compounds were isolated and their structures were elucidated as cembrene A （1）, verticilla-4（20）,7,11-triene （2）, acetyl-ll-keto-β- boswellic acid （3）, 3-keto-tirucall-8,24-dien-21-oic acid （4）, arachidic acid （5）, palmic acid （6）, stearic acid （7）, 1,2-dihydroxynonadecone-3 （8） and glyceryl monopalmitate （9）. CONCLUSION： Compounds 7-9 were isolated from this genus for the first time. Compounds 3 and 4 showed proliferation inhibition activity against Bel-7402, MCF-7, SMMC-7721, K562 and Hela. |
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| Keywords: | Boswellia carterii Birdwood(Frankincense) Chemical constituents Anti-tumor |
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