| 血管内皮生长因子靶向抗肿瘤药物的研究与开发 |
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| 引用本文： | 张艳丽,张娟,王旻. 血管内皮生长因子靶向抗肿瘤药物的研究与开发[J]. 国外医学(肿瘤学分册), 2007, 0(4) |
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| 作者姓名： | 张艳丽 张娟 王旻 |
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| 作者单位： | 中国药科大学生命科学与技术学院分子生物学教研室，中国药科大学生命科学与技术学院分子生物学教研室，中国药科大学生命科学与技术学院分子生物学教研室 |
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| 摘 要： | 血管内皮生长因子(VEGF)家族在肿瘤血管生成与转移中起关键作用,从不同途径阻断VEGF的生物学作用可以达到治疗肿瘤的目的。目前以VEGF及其受体为靶标研究开发了抗体、可溶性受体、酪氨酸激酶抑制剂、核酸和多肽类药物,均取得了较好的进展。
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| 关 键 词： | 血管内皮生长因子类 受体 血管内皮生长因子 新生血管化 病理性 肿瘤 |
Research and development of anti-tumor drugs targeting vascular endothelial growth factor |
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| ZHANG Yan-li ZHANG Juan. Research and development of anti-tumor drugs targeting vascular endothelial growth factor[J]. Foreign Medical Sciences (Cancer Section), 2007, 0(4) |
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| Authors: | ZHANG Yan-li ZHANG Juan |
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| Affiliation: | ZHANG Yan-li ZHANG Juan. Department of Molecular Biology,School of Life Science and Technololgy,China Pharmaceutical University,Nanjing 210009,China |
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| Abstract: | Vascular endothelial growth factor(VEGF)family is vital for angiogenesis and metastasis of cancer.Studies demonstrate that blockade of VEGF activity can control the growth of tumor.Compounds such as antibody,soluble receptors,tyrosine kinase inhibitors,nucleonic acid and polypeptides are developed targeting VEGF and its receptors. |
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| Keywords: | Vascular endothelial growth factors Receptor vascular endothelial growth factor Neovascularization pathologic Neoplasms |
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