胎盘组织COMT的表达及其与子痫前期发病的关系

目的：检测子痫前期患者胎盘组织儿茶酚氧位甲基转移酶（COMT）的表达,探讨其与子痫前期发病的关系.方法：收集15例子痫前期患者（子痫前期组）及15例健康妊娠妇女（对照组）的临床资料及产后胎盘组织,采用实时荧光定量聚合酶链反应（PCR）技术检测2组妊娠妇女胎盘组织COMT mRNA的水平.结果：子痫前期组胎盘组织COMT mRNA水平明显低于对照组（P＜0.001）,且胎盘组织COMT mRNA水平与血清尿酸、24 h尿蛋白定量、平均动脉压呈负相关（均P＜0.001）.结论：COMT在子痫前期妊娠妇女胎盘组织中呈低表达,可能与子痫前期的发病有关.

Expression of Catechol-O-Methyltransferase in Placenta and Its Relationship with Preeclampsia

Objective：To invesligate tire expression of catechol-O-methyl- transferase（COMT） in placenta from patients whh preetdampsia and the relationship between COMT and the pathogenesis of preeclampsia. Methods：15 patients with preeclampsia and 15 normal pregnant women were enrolled. Clinical characteristics and placental tissue were collected. placental COMT expression was determined by quantitative real-time PCR technique. Results：The level of COMT mRNA in Placenta from the preeclampsia group was significantly decreased than that in the normal pregnant women （P〈0.001）.Adjusted hy age and body mass index（ BMI ） ,the COMT expression was negatively correlated with serum uric acid ,24-hour urine protein and mean aftery pressure （all P〈0.001 ）. Conclusions：The decreased expression of COMT in placenta from preeclamptie patientssuggests that COMT may be involved in the pathogenesis of preeelampsia.