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Antiparasitic properties of homoallylamines and related compounds |
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| Authors: | Alicia Gómez-Barrio David Montero-Pereira Juan J Nogal-Ruiz José A Escario Susana Muelas-Serrano Vladimir V Kouznetsov Leonor Y Vargas Méndez Juan M Urbina Gonzáles Carmen Ochoa |
| Institution: | (1) Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain;(2) Laboratory of Fine Organic Synthesis, Research Center for Biomolecules, School of Chemistry, Industrial University of Santander, A.A. 678 Bucaramanga, Colombia;(3) Instituto de Química Médica (CSIC), Juan de la Cierva, 3, 28006 Madrid, Spain |
| Abstract: | A study of some antiparasitic properties of several homoallylamines and related tetrahydroquinolines and quinolines, previously described, was carried out using in vitro activity assays against the epimastigote form of Trypanosoma cruzi and against Trichomonas vaginalis. Unspecific cytotoxicity against murine macrophages was also studied. Although the antichagasic and trichomonacidal activities are not comparable to those of the standard drugs, nifurtimox and metronidazole, some of the compounds exhibit an interesting specific antiparasitic activity. |
| Keywords: | Homoallylamines tetrahydroquinolines quinolines antichagasic trichomonacidal unspecific cytotoxicity |
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