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| 酮洛芬醇质体凝胶的皮肤安全性实验 | |
| 引用本文： | 罗丽萍,韩瑞玲,王军,何文. 酮洛芬醇质体凝胶的皮肤安全性实验[J]. 中国药师, 2013, 16(8): 1114-1116 |
| 作者姓名： | 罗丽萍 韩瑞玲 王军 何文 |
| 作者单位： | 1. 武汉大学人民医院药学部 武汉430060 2. 武汉大学人民医院检验科 武汉430060 |
| 摘 要： | 目的:对酮洛芬醇质体(KPFE)凝胶的毒理进行研究,以评价其生物安全性.方法:以豚鼠为实验动物,分别观察其完整皮肤及破损皮肤短时间接触KPFE凝胶后所产生的毒性反应,完整皮肤及破损皮肤单次与多次接触KPFE凝胶后的局部刺激反应,并观察皮肤多次接触KPFE凝胶后机体免疫系统在皮肤上的反应.结果:KPFE凝胶在豚鼠完整或破损皮肤局部均无明显刺激性及毒性反应,多次使用后,未见明显的其他毒性反应.结论:KPFE凝胶具有较高的皮肤应用安全性,值得进一步研究. |
| 关 键 词： | 酮洛芬 醇质体凝胶 皮肤刺激性 |
| 收稿时间： | 2013-02-26 |
| 修稿时间： | 2013-04-18 |
Skin Safety Studies on Ketoprofen Ethosomal Gels |
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| Luo Liping,Han Ruiling,Wang Jun and He Wen. Skin Safety Studies on Ketoprofen Ethosomal Gels[J]. China Pharmacist, 2013, 16(8): 1114-1116 | |
| Authors: | Luo Liping Han Ruiling Wang Jun He Wen |
| Abstract: | ABSTRACT Objective: To study the toxicology of ketoprofen ethosomal (KPFE) gels to evaluate the bio safety. Method:Guinea pigs as the test animals, the toxicity in the complete and damaged skin treated by KPFE gels in a short time was observed, and the local irritation in the complete and damaged skin treated by KPFE gels with single or multiple dosage was studied. The general toxicity was also investigated after treated by KPFE gels for many times.Result:None of the tests showed the significant toxicity, local irritation or general toxicity. Conclusion:KPFE gels with promising skin application safety is valuable to be studied further. |
| Keywords: | Ketoprofen Ethosomal gels Skin irritation |
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