| 肺癌MRI与癌细胞核DNA含量及S期分数的相关性 |
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| 引用本文： | 许冬明 陈九如. 肺癌MRI与癌细胞核DNA含量及S期分数的相关性[J]. 中国医学计算机成像杂志, 2000, 6(3): 168-171 |
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| 作者姓名： | 许冬明 陈九如 |
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| 作者单位： | 上海市闸北区中心医院!200070(许冬明，陈九如)，甘泉医院放射科(杨振燕，詹松华)，上海市闸北区中心医院病理科(汤如勇，李日乐)，甘泉医院放射科 (周敏华) |
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| 摘 要： | 探讨肺癌ＭＲＩ信号及形态特征与ＤＮＡ倍体的关系。材料和方法：２６例原发性支气管肺癌患者，术前用Ｒｅｓｏｎｅｘ０．３８Ｔ磁共振成义行冠状面及横断面成像（ＳＥ Ｔ１ＷＩ和ＧＲ），增强后行横断面ＳＥ Ｔ１ＷＩ。术后肺癌标本用细胞图像分析仪，测定每例患者的ＤＮＡ含量及Ｓ期分数（ＳＰＦ）。结果：未增强Ｔ１ＷＩ异倍体肿瘤信号强度比显著大于二倍体肿瘤的信号强度比。异位体肿瘤的ＳＰＦ值也显著大于二倍体肿瘤，ＭＲＩ
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| 关 键 词： | 肺癌 MRI 信号强度 DNA含量 S期分数 |
Correlations of MRI,DNA Contents of Nucleaus and S - phase Fraction of Lung Cancer |
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| Xu Dongming,Chen Jiuru,Yang Zhenyan,et al.. Correlations of MRI,DNA Contents of Nucleaus and S - phase Fraction of Lung Cancer[J]. Chinese Computed Medical Imaging, 2000, 6(3): 168-171 |
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| Authors: | Xu Dongming Chen Jiuru Yang Zhenyan et al. |
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| Abstract: | Purpose: To explore the correlations of MRI, DNA contents and S - phase fraction (SPF) of lung cancer. Materials and Methods: Twenty six cases of lung cancer proved by surgery and pathology were examined with a 0. 38T MR system before operation. The pulse sequences includes SE T1 WI, gradient echo (GE) and Gd - DTPA - enhanced SE T1 WI sequences. DNA content was measured by an imaging analyzer (ICM - 100) and the SPF percentage was calculated. Results: Signal intensity ratios of lesion on unenhanced SE T1WI and SPF percentage were significantly smaller in diploid lesions than those in aneuploid lesions.Morphological characteristics of lung cancer on MRI couldn't reveal its DNA index and SPF. Conclusion: MRI signal - intensity ratios can reflect DNA ploidy in a certain degree. So, it can indirectly reflect the malignant biological behavior of lung cancer. |
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| Keywords: | Lung cancer MRI Singal - intensity DNA content S - phase fraction |
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