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| 桂辛通对糖尿病大鼠山梨醇及神经传导速度的影响 | |
| 引用本文： | 梁晓春,郝伟欣,贾力,徐惠媛,张克俭,郭赛珊,张宏,孙仁宇. 桂辛通对糖尿病大鼠山梨醇及神经传导速度的影响[J]. 中国中药杂志, 1999, 24(12): 749-751 |
| 作者姓名： | 梁晓春 郝伟欣 贾力 徐惠媛 张克俭 郭赛珊 张宏 孙仁宇 |
| 作者单位： | 中国医学科学院中国协和医科大学北京协和医院中医科 北京100730;中国医学科学院中国协和医科大学基础医学研究所 北京 100730 |
| 摘 要： | 目的:观察中药复方桂辛通对糖尿病大鼠山梨醇和神经传导速度的影响并探讨其作用机理。方法:采用链脲佐菌素糖尿病大鼠模型,给予中药复方桂辛通灌胃,并以氨基胍作为对照,观察对大鼠坐骨神经传导速度、坐骨神经组织和红细胞山梨醇(SNS) 浓度及醛糖还原酶(AR) 活性的影响。结果:用桂辛通治疗后,糖尿病大鼠坐骨神经传导速度增快,坐骨神经组织SNS 浓度降低,与糖尿病未治疗组及氨基胍组比较有显著差别。红细胞SNS,AR 与糖尿病未治疗组比较亦明显降低,但与氨基胍组比较无显著差别。结论:桂辛通对防治糖尿病神经病变有一定的作用,可能与抑制多元醇代谢途径的激活有关。 |
| 关 键 词： | 桂辛通 糖尿病大鼠 醛糖还原酶 山梨醇 |
| 收稿时间： | 1998-08-26 |
Effect of Gui Xin Tong on Sorbitol and Nerve Conduction Velocity in Diabetic Rats |
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| Liang Xiaochun;Hao Weixin;Jia Li;Xu Huiyuan;Zhang Kejian ; Guo Saishan;Zhang Hong ; Sun Renyu. Effect of Gui Xin Tong on Sorbitol and Nerve Conduction Velocity in Diabetic Rats[J]. China Journal of Chinese Materia Medica, 1999, 24(12): 749-751 | |
| Authors: | Liang Xiaochun Hao Weixin Jia Li Xu Huiyuan Zhang Kejian Guo Saishan Zhang Hong Sun Renyu |
| Abstract: | Objective:To investigate the effect of Gui Xin Tong(GXT) on sorbitol and nerve conduction velocity in diabetic rats.Method:The model rats suffering from diabetes were induced by STZ,and blood sugar levels above 16mmol/L were chosen for observation.The rats were divided into GXT group,AG group and control group.The nerve conduction velocity,aldose reductase activity and sorbitol in STZ induced diabetic rats were investigated.Result:Compared with the control group GXT could increase the sciatic nerve conduction velocity significantly (P<0.05),decrease the RBC and sciatic nerve,aldose reductase activity,and RBC sorbitol content.Conclusion:GXT has the effect of improving nerve conduction velocity significantly and reducing aldose reductase activity and sorbitol. |
| Keywords: | Gui Xin Tong(GXT) diabetic rats aldose reductase sorbitol |
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