| 乌司他丁对脓毒症大鼠心肌损伤的保护作用 |
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| 引用本文： | 肖雄箭,林建东,阙敢波. 乌司他丁对脓毒症大鼠心肌损伤的保护作用[J]. 中国现代医学杂志, 2008, 18(20) |
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| 作者姓名： | 肖雄箭 林建东 阙敢波 |
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| 作者单位： | 1. 福建医科大学附属第一医院ICU,福建福州,350005
2. 福建省龙岩市第二医院ICU,福建龙岩,364000 |
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| 摘 要： | 目的 探讨乌司他丁(ulinastatin,UTI)对脓毒症大鼠心肌损伤的保护作用.方法 63只SD大鼠随机分为假手术组(A组)、脓毒症组(B组)和乌司他丁组(C组),检测脓毒症前及脓毒症后3、6、12和24 h大鼠血浆TNI、BNP水平和心肌MDA含量、SOD活性,以及UTI的影响,并观察心肌组织超微结构变化.结果 脓毒症后3、6、12和24 h大鼠血浆TNI、BNP水平以及心肌MDA含量均显著高于假手术组(P＜0.05).心肌SOD活性低于假手术组(P＜0.05);UTI组较脓毒症组血浆TNI、BNP、心肌MDA明显降低(P＜0.05).心肌SOD活性明显升高(P＜0.05);UTI组心肌组织超微结构的损害较脓毒症组明显减轻.结论 脓毒症大鼠早期即发生明显的心肌损伤,乌司他丁能够显著减轻脓毒症时心肌损伤的程度,对脓毒症大鼠的心肌损伤有显著的保护作用.
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| 关 键 词： | 脓毒症 心肌损伤 超微结构 乌司他丁 |
Protective effects of Ulinastatin on myocardial injury in sepsis rats |
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| XIAO Xiong-jian , LIN Jian-dong , QUE Gan-bo. Protective effects of Ulinastatin on myocardial injury in sepsis rats[J]. China Journal of Modern Medicine, 2008, 18(20) |
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| Authors: | XIAO Xiong-jian LIN Jian-dong QUE Gan-bo |
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| Affiliation: | XIAO Xiong-jian1,LIN Jian-dong1,QUE Gan-bo2(1.ICU,the First Hospital Affiliated to Fujian Medical University,Fuzhou,Fujian 350005,P.R.China,2.ICU,the Second Hospital of Longyan,Longyan,Fujian 364000,P.R.China) |
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| Abstract: | Objective To investigate the protective effects of Ulinastatin(UTI) on myocardial injury in sepsis rats.MethodsSixty-three SD rats were randomly divided into three groups:sham operation group(Group A, n= 7), sepsis group(Group B, n=28) and Ulinastatin group(Group C, n=28).Plasma levels of troponin I(TnI), brain natriuretic peptide(BNP) and myocardial concentrations of malondial-dehyde(MDA), superoxide dismutase(SOD) were measured before and at 3, 6, 12 and 24 hours after sepsis respectively.Ultrastructive c... |
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| Keywords: | sepsis myocardial injury ultrastructure Ulinastatin |
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