| GSTT1及GSTM1和CYP2E1基因多态性与二甲基甲酰胺所致肝脏损害的关系 |
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| 引用本文： | 徐承敏,钱亚玲,朱丽瑾,项橘香,柴剑荣,阮征,张幸.GSTT1及GSTM1和CYP2E1基因多态性与二甲基甲酰胺所致肝脏损害的关系[J].中华劳动卫生职业病杂志,2007,27(1):333-337. |
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| 作者姓名： | 徐承敏 钱亚玲 朱丽瑾 项橘香 柴剑荣 阮征 张幸 |
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| 作者单位： | 浙江省医学科学院卫生学研究所,杭州,310013;杭州市余杭区疾病预防控制中心; |
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| 摘 要： | Objective To investigate abnormal liver function associated with polymorphism of GSTT1,GSTM1 and CYP2E1 in workers exposed to N,N- dimethylformamide.Methods Sixty-nine workers with abnormal liver function in a synthetic leather factory were recruited as case.One hundred and twenty five control subjects with similar work tasks were selected from the same factory.Genotypes for GSTT1 and GSTM1 were determined by multiplex PCR,and for CYP2E1 PstI by PCR-RFLP assay.Results The frequency of positive GSTM1 was 59.42% in cases and 38.40% in control,with an odds ratio (OR) of 2.34,95% CI:1.29～4.29 (P=0.005).For GSTT1 and CYP2E1 PstI,the frequencies of genotypes showed no significant difference between case and control.Conclusion GSTM1 positive genotype may be genetic risk factors for development of abnormal liver function in workers exposed to N,N- diroethylformamide.
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| 关 键 词： | 二甲基甲酰胺 多态性弹核苷酸 谷胱甘肽转移酶 |
Abnormal liver function associated with polymorphism of GSTT1,GSTM1 and CYP2E1 in workers exposed to N,N- dimethylformamide |
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| XU Cheng-min,QIAN Ya-ling,ZHU Li-jin,XIAN Ju-xiang,CHAI Jian-rong,RUAN Zheng,ZHANG Xing.Abnormal liver function associated with polymorphism of GSTT1,GSTM1 and CYP2E1 in workers exposed to N,N- dimethylformamide[J].Chinese Journal of Industrial Hygiene and Occupational Diseases,2007,27(1):333-337. |
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| Authors: | XU Cheng-min QIAN Ya-ling ZHU Li-jin XIAN Ju-xiang CHAI Jian-rong RUAN Zheng ZHANG Xing |
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| Abstract: | |
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| Keywords: | DimethylformamidePolymorphism single ancleotideGlutathione transferase |
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