牛磺酸颗粒的溶出度方法建立及国内产品质量现状考察

目的：建立牛磺酸颗粒的溶出度检查方法并对国内产品进行质量现状考察。方法：采用桨法50转，以水900mL为溶出介质，紫外．可见分光光度法测定，检测渡长333nm。结果：经方法学验证，牛磺酸检测浓度在80～400mg·L^-1范围内线性关系良好（r=0．9994），平均回收率为100．79％（RSD=1．32％）。且经用该法检验，国内5个厂家生产的牛磺酸颗粒在20min时，溶出度均不低于标示量的85％。结论：所建方法可行，准确灵敏，国内牛磺酸颗粒产品的溶出性能良好。

Establishment for the Determination Method of Dissolution of Taurine Granules and Comparison of Dissolution for Domestic Manufactures

Objective：The method for the determination of dissolution of Tanrine Granules was established and comparison of dissolution for domestic manufacture. Methods： The Apparatus 2 was used and water was used as dissolution medium; The absorbability was determined by ultraviolet Spectrophotometer with detection wavelength at 333 nm. Results： The method showed a good linear relationship in the range of 80 - 400 mg ·L ^- 1 （ r = 0. 999 4 ） with average recovery at 100. 79% （ RSD = 1.32% ）, and the dissolution of Tanrine Granules had achieved 85% in 20 min. Conclusion：This method is simple, accurate and reliable, and it satisfied for the determination of dissolution of Taurine Granules ; and domestic manufactures taurine granules have no significant differences between each other.