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Association of dopamine receptor polymorphisms with schizophrenia and antipsychotic response in a South Indian population |
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| Authors: | Neetha N Vijayan Sujatha Bhaskaran Linda V Koshy Chandrasekhar Natarajan Lekshmy Srinivas Chandrasekharan M Nair Priya M Allencherry Moinak Banerjee |
| Affiliation: | (1) Human Molecular Genetics Laboratory, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India;(2) Nair's Hospital, Ernakulam, Kerala, India;(3) Mental Health Centre, Kerala, India |
| Abstract: | BackgroundAlterations in the dopamine transmission and receptor density are hypothesized in the pathophysiology of schizophrenia but ethnic disparities are reported to exist in disease association and therapeutic response to psychotropic medication. Antipsychotics have higher binding affinity to D2 subtype of dopamine receptor. DRD2 Cys311, TaqIB1 and TaqIA1 variants are considered to have either reduced affinity for dopamine and hypo-dopaminergic activity. |
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