Clearance and dimensional changes of crocidolite asbestos fibers isolated from lungs of rats following short-term exposure |
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| Authors: | V L Roggli M H George A R Brody |
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| Affiliation: | 1. Division of Cardiology, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;2. Department of Occupational and Environmental Medicine, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;3. Department of Cardiology, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea;4. Centre for Population Health Sciences, University of Edinburgh, UK;5. Nutrition and Metabolism Unit, IDS Building, Southampton General Hospital (University of Southampton), MP 887, Southampton, UK;1. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, 171 77 Stockholm, Sweden;2. Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA;3. Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Room: E8527, Baltimore, MD 21205, USA;4. Functional Food and Metabolic Stress Prevention Laboratory, Center of Nutrition, Council for Agricultural Research and Economics, Via Ardeatina 546, 00100 Rome, Italy;5. Department of Surgical Sciences, Section of Orthopedics, Uppsala Clinical Research Center, Akademiska sjukhuset ing. 61 6 tr, 751 85 Uppsala, Sweden;6. Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Edificio U7, Via Bicocca degli Arcimboldi 8, 20126 Milan, Italy;7. Clinical Epidemiology Unit, T2, Department of Medicine, Karolinska Institutet, SE-171 76 Stockholm, Sweden;8. Department of Medicine, Karolinska University Hospital, Huddinge, C2:84, SE-141 86 Stockholm, Sweden |
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| Abstract: | ![]()
Previous studies in this laboratory have demonstrated fiber clearance and dimensional changes in chrysotile asbestos using a rat inhalational model of short-term exposure. The purpose of the present study was to determine whether or not similar changes occurred in crocidolite asbestos fibers isolated from the lungs of rats at various intervals after termination of exposure. Fibers were recovered on a membrane filter using a sodium hypochlorite digestion-concentration technique, and the numbers and dimensions of the fibers assessed using scanning electron microscopy. The mass of crocidolite asbestos retained in the lung was then calculated. Of the respirable fraction, 19% was deposited in the lungs, and 25% of this amount was still present 1 month after exposure. These values are similar to the 23% deposition and 19% retention rates for chrysotile determined in our previous study. There was a progressive increase in mean fiber length with time postexposure (P less than 0.05), but no significant changes in the diameter of the population of crocidolite fibers retained in the lung. Thus it appears that the tendency for longer fibers to be retained within lung tissue is a characteristic shared by serpentine and amphibole asbestos fibers, whereas longitudinal splitting with progressive decrease in mean fiber diameter in vivo occurs primarily with the serpentine fibers. |
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