两种方案治疗慢性乙型肝炎疗效对比及成本.效果分析

目的：寻找一种经济、有效、安全的治疗慢性乙型肝炎（CHB）方案。方法：将符合慢性乙型肝炎标准80例分成两组。分别以A方案（n=40）：注射用母牛分枝杆菌菌苗（微卡）＋乙肝疫苗＋潘生丁；B方案（n=40）：注射用重组人干扰素α1b（赛诺金）治疗。6个月为1个疗程。观察乙肝病毒的核糖核酸（HBV-DNA）、乙型肝炎e抗原（HBeAg）临床转阴率并做成本-效果分析。结果：两组有效率分别为87.5％和92．5％，两组比较差异无统计学意义（P〉0．05）；两组成本分别为3270．84元；10873、20元、A、B方案成本-效果比分别为37、38，117、55。结论：A方案为最佳治疗CHB经济、有效、安全的方案。

Contrast of Therapeutic Effects Between Two Schemes in Treating the CHB and the Cost-Effectiveness Analysis

Objective： To seek an economical effective and safe scheme for the treatment of CHB（ chronic hepatitis B）, Method： 80 cases of CHB were divided into two groups： Group A （n =40） ： treated with mycobacterium vaccine for injection（VACCAE） , HBB and dipyridamole In Groups B （n = 40） the medicine was recombinant human interferon α1b for injection（ SINOGEN）with one course of 6 months. The HBV-DNA, HBeAg and their clinical improvement rates were observed and the cost-effectiveness was analyzed, Result： The effective rates of 2 groups were 87.5% and 92, 5% respectively, No statistical difference（ P 〉 0. 05 ）was found in the 2 groups, The costs of the 2 groups were 3270、 84 yuan and 10 873, 20 yuan respectively, and the cost-effectiveness rates were 37, 38 and 117, 55 respectively. Conclusion： Scheme A is an effective, safe and economical scheme in the treatment of CHB.