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| 分子标记物在肺腺癌预后评估中的意义 | |
| 引用本文： | 周宝森,戴晓淳,何安光,杨春林,朱继江. 分子标记物在肺腺癌预后评估中的意义[J]. 中华流行病学杂志, 1998, 19(4): 231-233 |
| 作者姓名： | 周宝森 戴晓淳 何安光 杨春林 朱继江 |
| 作者单位： | |
| 基金项目： | 国家八五科技攻关资助项目 |
| 摘 要： | 对９３例肺腺癌患者做分子流行病学研究，应用免疫组织化学染色方法，用Ｃｏｘ多因素回归模型，分析ｐ２１例蛋白、ｐ５３蛋白、细胞增殖活性（ＰＣＮＡ）与预后的关系。结果表明：肺腺癌Ｐ２１蛋白阳性的，预后不好，表达阳性的死亡危险性是阴性的２．０８倍；Ｐ５３蛋白与肺腺癌预后无关；ＰＣＮＡ阳性百分比高的，预后不好，肺腺癌ＰＣＮＡ阳性百分比５０％以上的死亡危险性是肺腺癌ＰＣＮＡ阳性百分比２０％以下的３．２７倍。 |
| 关 键 词： | 腺癌 肺肿瘤 分子标记物 P21基因 P53基因 |
| 收稿时间： | 1998-04-07 |
| 修稿时间： | 1998-05-04 |
Molecular Marker As An Indicator in Presaging Prognosis of Human Lung Adenocarcinoma |
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| Zhou Baosen,Dai Xiaochun,He Anguang. Molecular Marker As An Indicator in Presaging Prognosis of Human Lung Adenocarcinoma[J]. Chinese Journal of Epidemiology, 1998, 19(4): 231-233 | |
| Authors: | Zhou Baosen Dai Xiaochun He Anguang |
| Affiliation: | Department of Epidemiology, China Medical University, Shenyang. |
| Abstract: | The paper discusses 93 cases of human lung adenocarcinoma in terms of molecular-epidemiology. The relationship between p21 protein and p53 protein and proliferating cell nuclear antigen (PCNA) was analysed by immunohischemical methods. Prognosis by Cox model was used for prosnosis prediction of adenocarcinoma in human lung. Results showed that the prognosis of adenocarcinoma was poor when of p21 protein expression was positive and the relative ratio was 2.08. However, p53 protein expression was not related to the prognosis of adenocarcinoma. The higher the positive rate of PCNA was, the poorer the prognosis of adenocarcinoma oppeared, with a ratio of 3.27. |
| Keywords: | Lung, adenocarcinoma p21 Protein p53 Protein Proliferating cell nuclear antigen(PCNA) |
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