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Pathology of inverted Takotsubo cardiomyopathy
Authors:Sylvestre Mar  chaux, Paul Fornes, St  phanie Petit, Catherine Poisson, Didier Thevenin, Thierry Le Tourneau, Philippe Asseman, Patrick Bruneval,Pierre-Vladimir Ennezat
Affiliation:aEchocardiography and Physiology Laboratories, Lille Medical University Center, Lille, France;bDepartment of Pathology, European G. Pompidou Hospital, Paris, France;cIntensive Care Unit and Department of Pathology, Lens Hospital Center, Lens, France;dIntensive Care Unit, Lille Medical University Center, Lille, France
Abstract:Myocardial dysfunction without coronary involvement may occur in acute cerebral diseases. The inverted Takotsubo pattern has been recently recognized as a novel heart neurologic stress-related syndrome. We report on the case of a 40-year-old woman presenting with massive subarachnoid hemorrhage and brain death. Echocardiography revealed an extensive left ventricular circumferential akinesis except at the apex. Histologic analysis of the heart confirmed the absence of myocardial infarction and revealed only sparse foci of myocyte necrosis with contraction bands in the akinetic areas.
Keywords:Inverted Takotsubo cardiomyopathy   Acute neurologic disorders
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