A study on the expression of TGF-beta 1/T beta R II in laryngeal carcinoma] |
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| Authors: | Shuzhi Yang Lingxiang Li Jun Han Haiyan Chen Wei Zhang Erzhong Fan Ying Li |
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| Affiliation: | Department of Otolaryngology, Inner Mongolia Hospital, Huhehaote 010070. |
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| Abstract: | OBJECTIVE: To explore the expression of TGF-beta 1/T beta R II in laryngeal carcinoma. METHOD: Immunohistochemical study using SP kit in 53 cases. RESULT: The expression of TGF-beta 1 was decreased in carcinoma tissues when compared with peri-cancer controls (P < 0.05). There wasn't difference in T beta R II expression when compared with peri cancer controls (P > 0.05). But it was correlated with the stage, differentiation and lymph node metastasis of laryngeal carcinoma. CONCLUSION: TGF-beta 1/T beta R II may involve in the histogenesis and development of laryngeal carcinoma. The decreased expression of TGF-beta 1/T beta R II may serve as an important molecular marker of laryngeal carcinoma. |
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