腔隙性脑梗死患者超敏C反应蛋白及同型半胱氨酸水平与ESRS的关系

目的探讨腔隙性脑梗死患者超敏C反应蛋白(Hs-CRP)及同型半胱氨酸(Hcy)水平与ESSEN卒中危险评分的关系。方法 125例急性期腔隙性脑梗死患者按ESSEN卒中危险评分将腔隙性脑梗死患者分为低危组(38例)、高危组(71例)、极高危组(16例),进行血浆Hs-CRP和Hcy水平的测定,比较三组间的Hs-CRP和Hcy水平变化及与ESSEN卒中危险评分的关系。结果①Hs-CRP水平极高危组显著高于高危组和低危组,(5.00±2.83)ug.ml-1 VS(1.03±1.03)ug.ml-1(P<0.01);(5.00±2.83)ug.ml-1 VS(0.46±0.38)ug.ml-1(P<0.01),高危组显著高于低危组,(1.03±1.03)ug.ml-1VS(0.46±0.38)ug.ml-1(P<0.05),随着危险因素增加有上升趋势,且Hs-CRP水平同Essen评分呈显著正相关关系(r=0.652,P=0.000)。②血浆Hcy水平极高危组与低危、高危组比较差异有统计学意义(P<0.05);且血浆Hcy水平同Essen评分呈正相关关系(r=0.198,p=0.027)。③三组年龄、糖尿病患病率、吸烟率、LDL、HDL有统计学意义(P<0.05或<0.01);三组高血压患病率、TC、TG和BMI比较无统计学意义(P>0.05)。结论腔隙性脑梗死患者的Hs-CRP和血浆Hcy水平变化在一定程度上反映患者的危险程度,同Essen评分有良好的相关性。

The correlation of hs-CRP and homocystine level with ESRS in the patents with lacunar infarction

Objective To investigate the correlation of hs-CRP and homocystine(Hcy)level with Essen Stroke Risk Score(ESRS)in patients with lacunar infarction.Methods According to the ESRS,125 patients with lacunar infarction were divided into three groups:ow risk group(n=38);high risk group(n=71) and very high risk group(n=16),plasma Hs-CRP and Hcy levels were measured,the changes of hs-CRP and Hcy levels as well as the relationship of hs-CRP and Hcy levels with ESRS were oberved.Results ①Hs-CRP level in the very high risk group was significantly higher than that in the high risk group and low risk group,(5.00 ± 2.83) ug/mL VS(1.03 ± 1.03) ug/mL(P<0.01);(5.00 ± 2.83) ug/mL VS(0.46 ± 0.38) ug/mL(P<0.01),and the level of hs-CRP in the high risk group was significantly higher than low risk group,(1.03 ± 1.03) ug/mL VS(0.46 ± 0.38) ug/mL(P<0.05),with the increase of risk factors,the level of hs-CRP increased,the level of hs-CRP had a completely positie correlation with ESRS(r=0.652 p=0.000).②Plasma levels of Hcy among very high risk,low risk and high risk groups were significant different(P<0.05),and the level of plasma Hcy had a positive correlation with the ESRS(r=0.198,p=0.027).③The comparisons of age,the prevalence of diabetes,smoking arte,LDL,HDL among three groups were significantly different(P< 0.05 or P< 0.01),the comparisons of hypertension prevalence,TC,TG and BMI among three groups were not different significantly(P>0.05).Conclusion Hs-CRP and Hcy leves in the patients with lacunar infarction can reflect the risk degree of their conditions,and they also have a positive correlation with the ESRS.