肺心病血内皮素—1和一氧化氮含量变化

用放射免疫分析法及分光光度比色法测定３０例肺心病人血内皮素－１（ＥＴ－１）和一氧化氮（ＮＯ）含量及两者比值（ＥＴ－１／ＮＯ）。治疗前肺心病患者ＥＴ－１明显高于正常人，ＮＯＭ是氏于正常人，均Ｐ〈０．０１，ＥＴ－１／ＮＯ经正常人高；治疗后，ＥＴ－１显著降低，但仍高于正常人，ＮＯ无明显变化，ＥＴ－１／ＮＯ与 比较仍存在差异。表明肺心病治疗前后均有ＥＴ－１和ＮＯ失衡。提示ＥＴ－１，ＮＯ含量及比值变化 与肺

A Study on Changes of Plasma Endothelin 1 and Serum Nitric Oxide in Patients with Chronic Pulmonary Heart Disease.

Plasma Endothelin 1(ET 1) and serum nitric oxide(NO) were measured by radioimmunuassay(RIA) and spectrophotometric techniques in patients with cor pulmonale(group A). The results showed as follows:ET 1 was greatly higher before treatment in group A than that in control, NO was reversed(P<0 01). ET 1/NO was also higher in group A than that in control. After treatment, however, ET 1 was significantly decreased, but still higher than that in control(P<0 01), NO had no obvious change while ET 1/NO was also in a high level when compared with that in control. It is indicated that an imbalance always exist between ET 1 and NO in patients with cor pulmonale before and after treatment, which suggests that changes of ET 1 and NO are related to the pathophysiological process of cor pulmonale.