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| 基质金属蛋白酶与结直肠癌的侵袭和转移 | |
| 引用本文： | 张剑锋,高春芳. 基质金属蛋白酶与结直肠癌的侵袭和转移[J]. 国际外科学杂志, 2007, 34(5): 323-326 |
| 作者姓名： | 张剑锋 高春芳 |
| 作者单位： | 471031,洛阳,解放军第150中心医院全军肛肠外科研究所;471031,洛阳,解放军第150中心医院全军肛肠外科研究所 |
| 摘 要： | 结直肠癌的侵袭和转移是一个相当复杂的过程。基质金属蛋白酶（MMPs）其抑制剂（TIMPs）是细胞外基质降解过程中的重要酶类，与多种病理过程尤其是肿瘤的侵袭和转移有着密切的关系，并在此过程中发挥着重要的作用。现就MMPs、TIMPs的生物学作用及其与结直肠癌侵袭和转移的关系进行综述。 |
| 关 键 词： | 基质金属蛋白酶 基质金属蛋白酶抑制剂 结直肠癌 侵袭转移 |
| 修稿时间： | 2007-01-02 |
Matrix metalloproteinases in the invasion and metastasis of colorectal carcinoma |
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| ZHANG Jian-Feng,GAO Chun-Fang. Matrix metalloproteinases in the invasion and metastasis of colorectal carcinoma[J]. International Journal of Surgery, 2007, 34(5): 323-326 | |
| Authors: | ZHANG Jian-Feng GAO Chun-Fang |
| Affiliation: | Research Institute of Anal-Colorectal Surgery, No. 150 Center Hospital of PLA, Luoyang 471031, China |
| Abstract: | The invasion and metastasis of colorectal carcinoma is a very complicated process. Matrix metalloproteinases (MMPs) and tissue inhibitor of matrix metalloprotenases (TIMPs) are critical enzymes for extracellular matrix disposing process, which closely associate with many pathologic courses, particularly with cancer invasion and metastasis, and play an important role in the invasion and metastasis process. This study summarized biological function of MMPs and TIMPs and their roles in the invasion and metastasis of colorectal carcinoma. |
| Keywords: | matrix metalloproteinases tissue inhibitor of metalloprotenases colorectal carcinoma invasion metastasis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |