|
|||||
|
|
Increased fMRI signal with age in familial Alzheimer's disease mutation carriers |
|
| Authors: | Braskie Meredith N Medina Luis D Rodriguez-Agudelo Yaneth Geschwind Daniel H Macias-Islas Miguel Angel Cummings Jeffrey L Bookheimer Susan Y Ringman John M |
| Affiliation: | a Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA b Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA c National Institute of Neurology and Neurosurgery, Mexico City, Mexico d Department of Neuroscience, University of Guadalajara, Guadalajara, Mexico e Semel Institute for Psychiatry and Human Behavior, UCLA, Los Angeles, CA, USA |
| Abstract: | Although many Alzheimer's disease (AD) patients have a family history of the disease, it is rarely inherited in a predictable way. Functional magnetic resonance imaging (fMRI) studies of nondemented adults carrying familial AD mutations provide an opportunity to prospectively identify brain differences associated with early AD-related changes. We compared fMRI activity of 18 nondemented autosomal dominant AD mutation carriers with fMRI activity in eight of their noncarrier relatives as they performed a novelty encoding task in which they viewed novel and repeated images. Because age of disease onset is relatively consistent within families, we also correlated fMRI activity with subjects' distance from the median age of diagnosis for their family. Mutation carriers did not show significantly different voxelwise fMRI activity from noncarriers as a group. However, as they approached their family age of disease diagnosis, only mutation carriers showed increased fMRI activity in the fusiform and middle temporal gyri. This suggests that during novelty encoding, increased fMRI activity in the temporal lobe may relate to incipient AD processes. |
| Keywords: | PSEN1 APP fMRI Familial Alzheimer's disease |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |