|
|||||
|
|
Age-related decline in white matter tract integrity and cognitive performance: A DTI tractography and structural equation modeling study |
|
| Authors: | Aristotle N. Voineskos Tarek K. RajjiNancy J. Lobaugh Dielle MirandaMartha E. Shenton James L. KennedyBruce G. Pollock Benoit H. Mulsant |
| Affiliation: | a Geriatric Mental Health Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada b Department of Neuroscience, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada c Cognitive Neurology, Sunnybrook Health Sciences Centre, Department of Medicine, University of Toronto, Toronto, Ontario, Canada d Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States e VA Boston Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA, United States f Rotman Research Institute, Baycrest Hospital, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada |
| Abstract: | Age-related decline in microstructural integrity of certain white matter tracts may explain cognitive decline associated with normal aging. Whole brain tractography and a clustering segmentation in 48 healthy individuals across the adult lifespan were used to examine: interhemispheric (corpus callosum), intrahemispheric association (cingulum, uncinate, arcuate, inferior longitudinal, inferior occipitofrontal), and projection (corticospinal) fibers. Principal components analysis reduced cognitive tests into 6 meaningful factors: (1) memory and executive function; (2) visuomotor dexterity; (3) motor speed; (4) attention and working memory; (5) set-shifting/flexibility; and (6) visuospatial construction. Using theory-based structural equation modeling, relationships among age, white matter tract integrity, and cognitive performance were investigated. Parsimonious model fit demonstrated relationships where decline in white matter integrity may explain age-related decline in cognitive performance: inferior longitudinal fasciculus (ILF) with visuomotor dexterity; the inferior occipitofrontal fasciculus with visuospatial construction; and posterior fibers (i.e., splenium) of the corpus callosum with memory and executive function. Our findings suggest that decline in the microstructural integrity of white matter fibers can account for cognitive decline in normal aging. |
| Keywords: | Aging Anisotropy Cognition Diffusion tensor imaging White matter |
| 本文献已被 ScienceDirect 等数据库收录！ | |