母牛分枝杆菌菌苗治疗菌阳肺结核的疗效评价

目的　评价化疗并用母牛分枝杆菌菌苗 (微卡菌苗 )治疗菌阳肺结核的疗效。方法　将 191例初、复治菌阳肺结核患者随机分为 A、B、C、D组 ,A、C组 (各 5 0例 )分别采用 2 HRZS/ 4 HR和 2 HRZES/ 6 HRE加微卡菌苗方案治疗 ;B组 (46例 )、D组 (45例 )单纯用 2 HRZS/ 4 HR和 2 HRZES/ 6 HRE方案治疗。观察治疗后肺部病灶吸收、痰菌阴转情况。结果　第 2月末痰菌阴转率 :A、B组分别为 96 .0 %和 78.3% ;C、D组分别为 92 .0 %和 6 8.9% ;疗程结束痰菌阴转率 A、B组分别为 98.0 %和 87.0 % ;C、D组 96 .0 %和 77.8%。疗程结束胸片改善有效率 A、B组96 .0 %和 84 .8% ;C、D组 92 .0 %和 73.3%。空洞闭合 A、B、C、D组分别为 83.33%、5 2 .6 3%、78.5 7%、4 5 .0 0 %。结论　微卡菌苗能提高痰菌阴转率 ,促进病灶吸收 ,是一种较好的免疫制剂。

Effect and evaluation of postitive bacteria pulmonary tuberculosis treated with chemotherapy and Mycobacterium vaccae vaccine

Objective To observe and evaluate the curative effect of postitive bacteria pulmonary tuberculosis treated with chemotherapy and Mycobacterium vaccae vaccine.Methods 191 primary and re-treated positive bacteria pulmonary tuberculosis cases were separated into group A,B,C,D at random.Group A(50 cases) and group C(50 cases )were treated with 2HRZS/4HR and 2HRZES/6HRE plus Mycobacterium vaccae vaccine .Group B(46 cases )and group D(45 cases)treated with 2HRZS/4HR and 2HRZES/6HRE alone.Then observe the foci absorption and the sputum negative conversion. Results At the end of 2 months ,the sputum negative conversion rate to group A,B,C,D was separately 96.0%,78.3%,92.0% and 68.9%.At the end of treatment,the sputum negative conversion rate to group A,B,C,D was separately 98.00%,87.00%,96.00% and 77.8%;the foci absorpation rate to group A,B,C,D was separately 96.00%,84.80%,92.00% and 73.3%;cavity close up was separately 83.33%,52.63%,78.57% and 45.00%.Conclusion Mycobacterium vaccae vaccine can improve the sputum negative conversion rate,accelerate the foci absorption.It is a better immunity injection.