| Graves病患者血清sCTLA-4测定及临床意义 |
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| 引用本文： | 金四丽,陈绍仁. Graves病患者血清sCTLA-4测定及临床意义[J]. 齐齐哈尔医学院学报, 2003, 24(8): 846-846,848 |
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| 作者姓名： | 金四丽 陈绍仁 |
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| 作者单位： | 上海市市北医院检验科,200435;齐齐哈尔医学院免疫学教研室 |
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| 摘 要： | 目的 研究Graves病患者血清中sCTLA—4表达及与甲状腺自身抗体TPO—Ab、TG—Ab和甲状腺激素FT3、FT4相关性在Graves病发病中的作用。方法 以ELISA ABC—HRP法测定sCTLA—4;以ELISA双抗法规定TPO—Ab、TG—Ab;以电化学发光法测定FT3、FT4。结果 实验组sCTLA—4水平与对照组相比明显升高(P<0.01),但与TPO—Ab、TG—Ab相关性不显著(P>0.05,P>0.05),与FT3、FT4亦无明显相关性(P>0.05,P>0.05)。结论 sCTLA—4可能在Graves病的发病机理中发挥重要作用,但作用机制似与甲状腺自身抗体TPO—Ab、TG—Ab及甲状腺激素FT3、FT4无关。
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| 关 键 词： | 可溶性细胞毒T淋巴细胞相关抗原4(sCTLA-4) graves病 |
Expression of sCTLA-4 in Sera from Patients with Graves Disease. |
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| Jin Sili,et al.. Expression of sCTLA-4 in Sera from Patients with Graves Disease.[J]. Journal of Qiqihar Medical College, 2003, 24(8): 846-846,848 |
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| Authors: | Jin Sili et al. |
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| Abstract: | Objective To study the expression of sCTLA-4 and its association with TPO-Ab, TG -Ab, FT3, FT4 in patients with Graves disease. Methods ELISA and ELECSYS were used for the detection of sCTLA- 4, TPO-Ab, TG-Ab and FT3, FT4. Results The level of sCTLA-4 was remarkably increased (P < 0, 01) in sera from patients with Graves disease but significant association of sCTLA -4 with TPO-Ab, TG-Ab, FT3, FT4 was not observed. Conclusions The results suggest that sCTLA-4 may play an important role in Graves disease, but it seems that the effect of sCTLA-4 has no remarkable relation to the TPO-Ab, TG-Ab, FT3, FT4. |
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| Keywords: | sCTLA-4 Graves disease (GD) |
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