| 内皮细胞性一氧化氮合酶基因多态性与缺血性脑卒中的相关性研究 |
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| 引用本文： | 朴翔宇,陶定波. 内皮细胞性一氧化氮合酶基因多态性与缺血性脑卒中的相关性研究[J]. 临床神经病学杂志, 2003, 16(4): 199-201 |
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| 作者姓名： | 朴翔宇 陶定波 |
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| 作者单位： | 116001,辽宁省大连医科大学第四临床学院神经内科;大连医科大学第一临床学院神经内科 |
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| 摘 要： | 目的 探讨大连地区汉族人内皮细胞性一氧化氮合酶 (ecNOS)基因多态性与缺血性脑卒中的关系。方法 应用聚合酶链反应对 170例缺血性脑卒中群体及 90例非脑血管病群体ecNOS基因第 4号内含子多态性进行分析。结果 在缺血性脑卒中组中 ,高血压、糖尿病、吸烟、纤维蛋白原、颈内动脉狭窄与对照组比较 ,有显著性差异 (均P <0 .0 5 )。非条件性Logistic回归分析证实 ,ecNOS基因多态性不是缺血性脑卒中的独立危险因素。结论 ecNOS 4a/b基因多态性与大连地区汉族人缺血性脑卒中无相关性
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| 关 键 词： | 缺血性卒中 内皮细胞性一氧化氮合酶 基因 多态现象 |
| 文章编号： | 1004-1648(2003)04-0199-03 |
| 修稿时间： | 2002-11-27 |
Correlative study between polymorphism in ecNOS gene and ischemic stroke |
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| Piao Xiangyu,Tao Dingbo. Correlative study between polymorphism in ecNOS gene and ischemic stroke[J]. Journal of Clinical Neurology, 2003, 16(4): 199-201 |
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| Authors: | Piao Xiangyu Tao Dingbo |
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| Affiliation: | Piao Xiangyu,Tao Dingbo.Department of Neurology,The Fourth Affiliated Hospital,Da Lian Medical University,Dalian 116001,China |
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| Abstract: | Objective To detect the relationship between ecNOS gene polymorphism and ischemic stroke in Dalian,China.Methods The polymorphism of intron 4 of ecNOS gene was analyzed in normal group(90 cases) and ischemic stroke group(170 cases) by a combination of polymerase chain reaction(PCR).Results In ischemic stroke group,hypertension, diabete mellitus, smoking, fibrinogen and internal carotid artery narrow were significantly different from those of control group(all P <0.05). The stepwise multiple regression Logistic analysis in all patients showed that ecNOS gene polymorphism was not an independent risk for ischemic stroke.Conclusion There is no association between ecNOS4a/b gene polymorphism and ischemic stroke in Dalian, China. |
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| Keywords: | Ischemic stroke Endothelial nitric oxide synthase Gene Polymorphism |
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