同种异体子宫移植的研究进展

近十余年来,随着显微缝合技术的成熟和免疫抑制剂的广泛应用,子宫移植技术已取得显著临床进展。目前,国内外已成功开展总计近40余例人体子宫移植手术并获得12例活产分娩的健康新生儿,这表明子宫移植技术已成为重建子宫性不孕女性个体生殖能力的重要手段。但目前子宫移植技术尚未成熟开展,供受体配型、子宫体外灌注、术后免疫抑制方案和免疫排斥的诊断等问题值得关注。本文对同种异体子宫移植的研究进展做一综述。

Research progress in uterus allotransplantation

The application of microsurgery and immunosuppressive agents have led to remarkable progress in uterus allotransplantation for patients with absolute uterine infertility.At present,more than 40 cases of human uterus transplantation have been successfully carried out worldwide,and 12 healthy newborn babies have been delivered using cesarean section.However,selection of transplant donors and recipient,in vitro uterine perfusion,the immunosuppressive therapy and characteristics of graft rejection after uterus allotransplantation are worthy of attention.This article reviews the research progress in uterus allotransplantation.